{"metadata":{"accession":"D7R609","id":"D7R609_EPICO","source_organism":{"taxId":"94232","scientificName":"Epinephelus coioides","fullName":"Epinephelus coioides (Orange-spotted grouper)"},"name":"Dicarboxylate carrier UCP2","description":["Antiporter that exports dicarboxylate intermediates of the Krebs cycle in exchange for phosphate plus a proton across the inner membrane of mitochondria, a process driven by mitochondrial motive force with an overall impact on glycolysis, glutaminolysis and glutathione-dependent redox balance. Continuous export of oxaloacetate and related four-carbon dicarboxylates from mitochondrial matrix into the cytosol negatively regulates the oxidation of acetyl-CoA substrates via the Krebs cycle, lowering the ATP/ADP ratio and reactive oxygen species (ROS) production. May mediate inducible proton entry into the mitochondrial matrix affecting ATP turnover as a protection mechanism against oxidative stress. The proton currents are most likely associated with fatty acid flipping across the inner membrane of mitochondria in a metabolic process regulated by free fatty acids and purine nucleotides"],"length":312,"sequence":"MVGFGPADVPPSAAVKFVGAGTAGCIADLVTFPLDTAKVRLQIQGEARAPVAAGKEYAVKYRGVFGTITTMVRTEGPRSLYSGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHVGIGSRLLAGCTTGAMAVAFAQPTDVVKVRFQAQARSPGCVRRYCSTVNAYKTIAKEEGIHGLWKGTAPNIARNAIVNCTELVTYDFIKDTLLRSTPLTDNLPCHFVSAFGAGLCTTVIASPVDVVKTRYMNAALSQYSSVLKCAAAMMTKEGPLAFYKGFMPSFLRLGSWNVVMFVTYEQLKRAMMAANHNCTTIL","proteome":null,"gene":"UCP2","go_terms":[{"identifier":"GO:0055085","name":"transmembrane transport","category":{"code":"P","name":"biological_process"}}],"protein_evidence":2,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"e037822792ef5f5d7967370632f8bf737b916266","counters":{"domain_architectures":140476,"entries":10,"isoforms":0,"proteomes":0,"sets":0,"structures":0,"taxa":1,"dbEntries":{"profile":1,"pfam":1,"ssf":1,"cathgene3d":1,"panther":1,"prints":1,"interpro":4},"proteome":0,"taxonomy":1,"similar_proteins":140476}}}