{"metadata":{"accession":"D3Z7E6","id":"D3Z7E6_MOUSE","source_organism":{"taxId":"10090","scientificName":"Mus musculus","fullName":"Mus musculus (Mouse)"},"name":"Platelet-activating factor acetylhydrolase IB subunit alpha1","description":["Alpha1 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. Both alpha1/alpha1 homodimer (PAFAH1B3/PAFAH1B3 homodimer) and alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B2 heterodimer) hydrolyze 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA) more efficiently than PAF, but they have little hydrolytic activity towards 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE). Plays an important role during the development of brain"],"length":180,"sequence":"MHQCEIWRELFSPLHALNFGIGGDSTQHVLWRLENGELEHIRPKIVVVWVGTNNHSHTAEQVTGGIKAIVQLVNKLQPQARVVVLGLLPRGQHPNPLREKNRQVNELVRAALAGYPRAHFLDADPGFVHSDGTISHHDMYDYLHLSRLGYTPVCRALHSLLLRLLAQDQGQGIPLPETAS","proteome":"UP000000589","gene":"Pafah1b3","go_terms":null,"protein_evidence":1,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"30e8efcaaad38566460605bbc3ff761efe17bab4","counters":{"domain_architectures":101760,"entries":7,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cdd":1,"cathgene3d":1,"ssf":1,"pfam":1,"panther":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":101760}}}