{"metadata":{"accession":"C9Z8F7","id":"C9Z8F7_STRSW","source_organism":{"taxId":"680198","scientificName":"Streptomyces scabiei (strain 87.22)","fullName":"Streptomyces scabiei (strain 87.22)"},"name":"Serine hydroxymethyltransferase","description":["Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of L-allo-threonine"],"length":412,"sequence":"MSVTPVLEADVLRRQDPELADILLGELDRQATTLQLVAAENFTSPAVLAALGSPLANKYAEGYPGARHHGGCEMVDVAERLAVERARSLFGAAHANVQSHSGSSAVLAAYAALLRPGDTVLAMGLHFGGHLTHGSPANFSGRWFDFVGYGVEAESGLIDHEQVRTLARTHRPKAVVCGSISYPRHIDYAFFREVADEVGAYLIADAAHPIGLVAGGAAPSPVPYADIVCATTHKVLRGPRGGMLLCGDELAERVDRAVFPFTQGGAQMHTIAAKAVAFGEAATPAFTAYAHQVVANARVLARGLAEEGLVVVTGGTDTHLLTVDPAPLGVDGRTARGRLAAAGMVLDCCALPHGDARGLRLGTAALTTQGMGETEMARLAVLFAGALREGGDGKRTREEVRDLAGRFPPYPR","proteome":"UP000001444","gene":"glyA","go_terms":[{"identifier":"GO:0004372","name":"glycine hydroxymethyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0030170","name":"pyridoxal phosphate binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0019264","name":"glycine biosynthetic process from L-serine","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0035999","name":"tetrahydrofolate interconversion","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"a467f6dfa8ae11c9935b71e94ed54da4f6601504","counters":{"domain_architectures":46777,"entries":15,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"pfam":1,"cdd":1,"cathgene3d":2,"pirsf":1,"hamap":1,"panther":1,"ncbifam":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":46777}}}