{"metadata":{"accession":"C5B8M5","id":"C5B8M5_EDWI9","source_organism":{"taxId":"634503","scientificName":"Edwardsiella ictaluri (strain 93-146)","fullName":"Edwardsiella ictaluri (strain 93-146)"},"name":"Dihydrofolate synthase/folylpolyglutamate synthase","description":["Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives"],"length":423,"sequence":"MNTLPTPLATSPLSTWLDYLENLHSKSIDLGLDRVRHVAQRLDLLTPAPVVYTVAGTNGKGTTCRTLEAILMAAGYRVGVYGSPHLLHYRERVRIQHRELDDAAHAAAFAAVEAGRDGVSLTYFEFGTLAALYLFKQAALDAVILEVGLGGRLDATNIVDPSVAVVTSIALDHTDWLGDTRESIGREKAGIFRDAAPAVVGEPDMPDSIGAVAQACGAHLLRRGVDWDFSVEAQGWRWHDATRHVEGLPLPQVPLANAATALTALSYGPLPVDDAAIRQGLRDAVLPGRFQQLSESPRLILDVAHNPHAAAYLAQRLRTLPQRGRLRMVIGMLSDKDIAGTLACLIPLVDQWYCAPLEGPRGAAVLALMAHLPADAQTFGGVELAWRQAMADAAADDTVVVCGSFHTVAHVMAALASGETGGK","proteome":null,"gene":"NT01EI_2717","go_terms":[{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0009058","name":"biosynthetic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016881","name":"acid-amino acid ligase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004326","name":"tetrahydrofolylpolyglutamate synthase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0009396","name":"folic acid-containing compound biosynthetic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"e6ab2b5b1f832ff43dbb14fcfeb9fea358486a52","counters":{"domain_architectures":37786,"entries":17,"isoforms":0,"proteomes":0,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"pfam":2,"ncbifam":2,"pirsf":1,"panther":1,"prosite":1,"interpro":6},"proteome":0,"taxonomy":1,"similar_proteins":37786}}}