{"metadata":{"accession":"B8BNY8","id":"JIYAO_ORYSI","source_organism":{"taxId":"39946","scientificName":"Oryza sativa subsp. indica","fullName":"Oryza sativa subsp. indica (Rice)"},"name":"Meiotic drive suppressor JIEYAO","description":["Antidote component of the DUYAO/JIEYAO poison/antidote system that promotes unequal transmission of alleles into progeny and plays a role in hybrid male sterility (PubMed:37499659). The poison DUYAO acts in a sporophytic manner and inhibits mitochondrial function by sequestering the cytochrome c oxidase assembly protein COX11, leading to pollen death (PubMed:37499659). Binding of antidote JIEYAO, which acts in a gametophytic manner, reroutes the poison from the mitochondrion to the autophagosome for degradation, and leads to production of fertile pollen (PubMed:37499659)"],"length":523,"sequence":"MTMEDGSCPSPVTPSEAEAGAEDYESWTLKQKIEDLVNCDPIHGIMPKNPKYKAYFEEKFQEKLSKYVRVVLPKLRPAIQKDSVKQFFQVYNCWSGFMGRGNFLLPDILTNMANKNALRCARVALQGTSPLLRRRRADPNTRHRYGFAPLHMAAENFSVDMVKLLFRYGASANIRTKGEYVIEGLLPLHVAVENASMHKYIEDHWAHGDHIINLIFLLCLPEMKMFLDTTRLIAKQTDNIVDEVWNYIREEKHVQAAILLLAAQKQLRGRLNNSSGKASLNGFDIVKSHIDDALNTIHLEGLNMVKEGKNGRALKRLKDKKEALLTALVLVGIVHKAGEALEGYIQTHSQVRHDEIVEHVSSILKSNGIAHSGESIDTGKLECYQHGGGMSIGKSDSQRVGYGETIEADKSSSDIGEVSKMILGKQPPKGSAIREVRDMFFPYWKSVLSRRLQLKIVPSCQLSRKDLLSAEASTKGTKSIDHPCNPIKSMGNLGSMGWPPLSSESRRMLYTVASMSRKVFKRT","proteome":"UP000007015","gene":"JIEYAO","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"806c73e0acb4162043e826e0994378eaf9857d32","counters":{"domain_architectures":3037,"entries":10,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":1,"smart":1,"profile":2,"panther":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":3037}}}