{"metadata":{"accession":"B6I635","id":"GRPE_ECOSE","source_organism":{"taxId":"409438","scientificName":"Escherichia coli (strain SE11)","fullName":"Escherichia coli (strain SE11)"},"name":"Protein GrpE","description":["Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding"],"length":197,"sequence":"MSSKEQKTPEGQAPEEIIMDQHEEIEAVEPEASAEQVDPRDEKIANLEAQLAEAQTRERDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAKAKA","proteome":null,"gene":"grpE","go_terms":[{"identifier":"GO:0000774","name":"adenyl-nucleotide exchange factor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0042803","name":"protein homodimerization activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0051087","name":"protein-folding chaperone binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006457","name":"protein folding","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"bcfacd3ac840c2030716357b736a826603778042","counters":{"domain_architectures":36652,"entries":16,"isoforms":0,"proteomes":0,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"cdd":1,"ncbifam":3,"hamap":1,"panther":1,"pfam":1,"prosite":1,"prints":1,"interpro":3},"proteome":0,"taxonomy":1,"similar_proteins":36652}}}