{"metadata":{"accession":"B1H2T7","id":"B1H2T7_XENTR","source_organism":{"taxId":"8364","scientificName":"Xenopus tropicalis","fullName":"Xenopus tropicalis (Western clawed frog)"},"name":"NADPH-dependent diflavin oxidoreductase 1","description":["NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair. In vitro can fully activate methionine synthase/MTR in the presence of soluble cytochrome b5/CYB5A"],"length":598,"sequence":"MPQRNLLILYGSQTGTAEDLAGRLGREAKRHHFQCRMESLDEYRVADLIHEPLVVFVCATTGQGDPPDNMKNFWRFIFRRNLPHNALCRMDYAVLGLGDSSYPKFNFIAKKLHKRLQQLGACPLLPPALGDDQHDLGPDAAVDPWLKDLWSKILSIYPLPPGLNIISEDILLPPKYLLRLLEETIGQDDLSGEELERDSNNTTPASESHPFPAPVVSNQRVTALDHFQDVRLIEFDISGSALQFSPGDVAMVQPRNSPPHVQQLCSLLRLDPRTRFVVEASDPEAAVPAQLAELQCIGQLAERYLDLCAVPRRSFFQLLSHFAPDELEREKLREFGSAGGQEELFSYCNRPRRTLLEVLVDFPHTTRCIPATYLLELIPRMRPRAFSIASSMQALPNALQILVAVVQYRSKLIEPRRGLCSTWLASLPPRGRERVPIWVKRGSMTFPLEPGTPLVMVGPGTGVAPFRAAVQERAANGKRWSCLFFGCRGKSKDFYFEKEWEDLVTGGFLTLFTAFSRDQEDKVYVQRRIRENSALLWDLLANRQGYFYIAGNAKSMPNEVTDALKWVLQSEGGLSAPDAEQYVVAMEKSRRFQSETWS","proteome":"UP000008143","gene":"ndor1","go_terms":[{"identifier":"GO:0010181","name":"FMN binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016491","name":"oxidoreductase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0160246","name":"NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":2,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"a940318bfe18887bd690aa0ff414b314e8cedbe8","counters":{"domain_architectures":17636,"entries":27,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":4,"ssf":3,"profile":2,"pfam":3,"panther":1,"hamap":1,"prints":2,"interpro":11},"proteome":1,"taxonomy":1,"similar_proteins":17636}}}