{"metadata":{"accession":"A8IQT2","id":"CCD40_CHLRE","source_organism":{"taxId":"3055","scientificName":"Chlamydomonas reinhardtii","fullName":"Chlamydomonas reinhardtii"},"name":"Coiled-coil domain-containing protein 40 homolog","description":["Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, by acting as a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (PubMed:25395538). Together with CCDC39/FAP59 forms a 96-nm-long complex in flagella. This complex does not act as a physical ruler, but rather act as a negative regulator for radial spokes: the complex lays along specific protofilaments, masking radial spoke binding sites and allowing recruitment of inner dynein arm (IDA) and nexin-dynein regulatory complexes (N-DRC) (PubMed:25395538)"],"length":576,"sequence":"MADPMDQPSTSDPVDNQIFGEQGGLRPDHPLLRRAQEALKVQFEANRTRLQEELREKANALKQAKARREALGVELYGFQQNLAKLQLNLETTHQNYQCEDQLNQLKQQLSLEEGDTKGERSRRVCVCVCRVCCRIDTLQDNLKGTQQQLALVSAQLEAQKRETRAALETLAEAEVGGCVRDEALSAIQDGMREQQQQELSLVLEIEGYKKDVVREQLKHESLTAVVRKVEGDAVFVQKQIEGAQERQARLQEILAKLAKSLEHTEAEGEADAVDRAITKVAAEGRAIEEEMLSALSDQTTAEKATSKTAADTQELRKRIRAEELAVVETENELAKLQVDILNTEAHNSRLGETLGLLDEELRDKGRTIEKYELEIKRRNDEIEKKTREIDILNRRRDCRGSAALDTRPLQAPPPPQVKSDLALTTPMYTPPPVPQPSVGMTVTTEKLVSDMEKALTKREIISVKGRATAAKSKSSTPAGSATASSRASPSASVASSTLTRNQLDRATTDLAKSIKDLEAGRYRPVVEDAAAVGEELGRAQDKLGRVVALLEGLRQAAPHLAGELDKVLCHVADVRA","proteome":null,"gene":"CCDC40","go_terms":[{"identifier":"GO:0035082","name":"axoneme assembly","category":{"code":"P","name":"biological_process"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":null,"counters":{"domain_architectures":0,"entries":2,"isoforms":0,"proteomes":0,"sets":0,"structures":0,"taxa":1,"dbEntries":{"panther":1,"interpro":1},"proteome":0,"taxonomy":1}}}