{"metadata":{"accession":"A6M6B3","id":"A6M6B3_9INFA","source_organism":{"taxId":"437353","scientificName":"Influenza A virus (A/swine/Tennessee/62/1977(H1N1))","fullName":"Influenza A virus (A/swine/Tennessee/62/1977(H1N1))"},"name":"Polymerase acidic protein","description":["Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity"],"length":716,"sequence":"MEDFVRQCFNPMIVELAEKTMKEYGENPKIETNKFAAICTHMEVCFMYSDFHFINERGESIIIEPSDSNALLKHRFEIIEGRDRNMAWTVVNSICNTTGVGKPRFLPDLYDYKEDRFIEIGVTRREVHIYYLEKANKIKSEETHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETIEERFEIKGTMRRLADQSLPPNFSSFDNFRAYVDGFEPNGYIEGKLSQMSREVNARIEPFLKTTPRPLRLPCGPPCFQRSKFLLMDALKLSIEDPSHEGEGIPLYDAVRCMKTFFGWKEPTIVKPHEKGINSNYLLAWKQVLAEIQDFEDEKKIPRVKNMKKTSPLKWALGENMAPEKVDFEDCKDVSDLKQYDGDEPEFRSLASWIQNEFNKACELTDSSWLELDEIGEDIAPIEHIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLELHKWEKYCILEIGDMVLRTAIGQVARPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNCLYASPQLEGFSAESRKLLLIVQALRDNLEPGTFDLGGLYESIEECLINDPWVLLNASWFNSFLTHALR","proteome":null,"gene":"PA","go_terms":[{"identifier":"GO:0003723","name":"RNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0039694","name":"viral RNA genome replication","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"0630fbd2b52ea34697c96d66cbb2d83eb22d9481","counters":{"domain_architectures":99195,"entries":6,"isoforms":0,"proteomes":0,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"hamap":1,"pfam":1,"interpro":3},"proteome":0,"taxonomy":1,"similar_proteins":99195}}}