{"metadata":{"accession":"A5DLC6","id":"ATG7_PICGU","source_organism":{"taxId":"294746","scientificName":"Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)","fullName":"Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast)"},"name":"Ubiquitin-like modifier-activating enzyme ATG7","description":["E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity (By similarity)"],"length":646,"sequence":"MIMTELRDLVGKPLKYVPTRSFVESSFFKALSDLKLNQLKLNTDTVSISGFMNHPKNLTKFQDYPILNLDFSSFELASSASSAASDENVEYKGTLLNVNTIEEFKAINKSDLLKQWGSLIYKSITEGDTTYRSVNQFFVLTFSDLKKYKFYYWFAYPSLQSQWTVKECKEAPSFEDETRKYLDTQEELEFFFAREQEEFCGLSKFLNGSKKVNEHSTFVFVDSCRHPGLYPGWQLKNFLYILARQGMREIRLFVYRYDGTSIMMKLQLDSIPNDIKFMGWERTKDDKLGPKLADLGSLIDPIQLADQAVDLNLKLMKWRISPQLNLEKVAQQKVLLLGSGTLGSYVARALMGWGVRHITFVDNGRVSYSNPVRQPLFGFNDCFSDEGLGRWKAPRAAEALKEIFPGVNSSAYNLEVPMIGHPVENEQSAKANYETLERLVDENDAIFLLMDSRESRWLPTLLGMAKNKLVINAALGFDSFLVMRHGTTTNNLGCYYCNDVVAPSDSLSDRTLDQMCTVTRPGGALMASALAVELLVSVLQHPEGAEADAKEHSFFGEVPHQIRGFLHNFSQTKLYAPKYTHCSACSQPVVDSFRSQGWDFVKNCLNDTKHLERVCGLEEVQREAERASEALLEQAAGLDLSDEEWL","proteome":"UP000001997","gene":"ATG7","go_terms":[{"identifier":"GO:0008641","name":"ubiquitin-like modifier activating enzyme activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005737","name":"cytoplasm","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"757f43e6b01bcfcb9c5c968cdfcd34b85c9d69b4","counters":{"domain_architectures":4710,"entries":15,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"pfam":2,"ssf":1,"ncbifam":1,"panther":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":4710}}}