{"metadata":{"accession":"A0AAX6TAP1","id":"A0AAX6TAP1_HETGA","source_organism":{"taxId":"10181","scientificName":"Heterocephalus glaber","fullName":"Heterocephalus glaber (Naked mole rat)"},"name":"Prostaglandin E synthase","description":["Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli. Plays a key role in inflammation response, fever and pain. Also catalyzes the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively"],"length":185,"sequence":"MPPSGLALADSRALPAFLLCSTLLVIKMYVVAVITGQVRLRKKAFANPEDALRHGGLQFCRSNPDVERCLRQATPGLGQDLAQIWLGLSCGSPKPGTQRVPSRAHRNDMETIYPFLFLGLVYCFLGPSPAAAWGHFLPFLLGRLLHTVAYLGQLRAPVRSLAYTVAQLPCASMALQILWEAARHL","proteome":"UP000694906","gene":"Ptges","go_terms":[{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"e2cf1f5163a84e238f4e7981be2ccc606dab93d5","counters":{"domain_architectures":28012,"entries":7,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":1,"panther":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":28012}}}