{"metadata":{"accession":"A0AAR5PP21","id":"A0AAR5PP21_DENPD","source_organism":{"taxId":"77166","scientificName":"Dendroctonus ponderosae","fullName":"Dendroctonus ponderosae (Mountain pine beetle)"},"name":"PAN2-PAN3 deadenylation complex subunit PAN3","description":["Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins"],"length":615,"sequence":"MDWLSPSSHPHSTLSQLGRTNHLTEFVPRMNNSTSTTSNSGFSCNSYAPMTPSVMFHSMPKKFDDQENIPKESVAPSPAHSSSPISHDKQMCSTNGTVVLPAYQENVGGTTYFYQYSTPPENNGETIPPEPVMSTATPASNEYVPFPGKSESSFFMSEELRNDILNRNLLSLLQPDPSQYPDLPQEVDSYHELYPLEPISNQVNILNVLHKAHLGYQASMYKATHIKNGVHYCLRRIHGFRLQNTKFISLVDLWKKLDHSNIVQLREVFTTKAFGDNSMVFVYSYHPGSETLLNKHFSIDQPGYHDPFSNDKSTPMPYSYQKTNLLRHQQNNKLPEPLIWNYIIQLTSALRVIHSNALACRSLDPTKIILTSKNRLRLSCLAVMDVVLHDSNSSLNHLALIHHYQQEDLTALGKLVLALACKSTVAVQRDNISTALDIVSRTYTIDLRNLIMYLLTNQRRSVTDLMPMIGARFYTQLDNLHSHVETLESEMCKEVQNGRLFRLMTKLAAINERPDFNMESTWSETGDRYMLKLFRDYVFHQVTEEGQPWIDMAHIVQCLNKLDVGAPEKICLMSRDEQSILVVSYAELRHCLDQSFQELSNSSVLQHELSVEDKI","proteome":"UP000019118","gene":"PAN3","go_terms":[{"identifier":"GO:0004672","name":"protein kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006468","name":"protein phosphorylation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003723","name":"RNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0000289","name":"nuclear-transcribed mRNA poly(A) tail shortening","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0031251","name":"PAN complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"d46c9b9e9abc93bd4542926912a8deec27bdf174","counters":{"domain_architectures":3126,"entries":12,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"profile":1,"ssf":1,"pfam":1,"hamap":1,"panther":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":3126}}}