{"metadata":{"accession":"A0AAN8AM68","id":"A0AAN8AM68_ELEMC","source_organism":{"taxId":"56733","scientificName":"Eleginops maclovinus","fullName":"Eleginops maclovinus (Patagonian blennie)"},"name":"RB1-inducible coiled-coil protein 1","description":["Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy. Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis. Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways. Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway through induction of RB1 expression. Plays a crucial role in muscular differentiation. Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis"],"length":1629,"sequence":"MKLYVFQVNNGSTLTFDTDLAVQTVLELKHAIQAKYKIAIQHQVLVVNGGECMAAERRVCSYSAGTETNPIFLFNKEMILCDRDPTIPKTTFSIESEIQVKVEESLLMPAVFHTVASRTQLALEMFEVAKKLCSFCERLVHDEHLQHQGWAAIMANLDDCTLSYQKLLMKFDSSYANYQHDLEQIKVKLSKLGTSVSVMARIPLLECLTRHSYKESMEKSSPTPGKDSDETEEEKSTDSVLCPTDAQRPSKSSASFSASGNATSQPTGDQETNEMTDSGGLRSALLDDDDDDDDVAELTNPSCFNVTLLDWINVQDRPNDVESVVRKCFDSINRLDPRIIQPFLTDCRDTIAKLDNQNMKAIKGLEDRLYALDQMIASCKKLVNEQKELAQGFLANQKRAENLKDTSVLPDLCLSHTNQLMIMLNNHRKLLDIKKKCTTAKQELANNLQVRLKWCCYVMLHADQDGEKLQALLRLLTELMERVRVVEALSTVPQMYCLAVVEVVRRKMFMRHYREWAYALVKDGKRLYEAEKFKRESFGKLFRKSFLRNRLFRGLDSWPPTSFCTRKPRRFDDELPDISVDDLQYLKSCCPTEVQPFLLFPSRVPTMCDFEPLNRHVETLHQLVKAAQSVDEMSQTITDLLNEQRTSYSQRSSVLTPQSGSMPGSSTPRSPKTPSSLNLQGPSCQPLHVPVPAPLEDLSPDSIDAQTFDFETIGHPNMDPVLQQGSLDLDSLAESPESDFMSAVNEFVIEVNLTSPNPTSDPTSPEMMGESLYSSVINAIDNKRMQDTTILERENSRIIVLKQEIDKYRSAAEESHSNFRSVKEDLHHLRGVVLKEQQDFGFVLRNMSTEVRTIVDNICEIHKLELKEQHESELLSLRQELEKQVQTLTEENQVNQNIVRDVQHAMLELEGHMERKEKELTQLENEKERWVETEGNQTGRIKNLEQMIGEQIEEIKTLSASKDSLTSQLENLHFEIERSQQKIRQELEVVEQSHLKQMEDKMKQEHADKLETLTKDNQEALKHLAAENSAKLIETADHHAATLKEKENQMKDLEARVTELAELRCKVEVELALKESETEELRLLFEETKSQQAETVTSQVDAATVALSEELAVMKQQLHVKNEEHEVGLAELRSMMRDEKDNCISELVDRHDEEIICLRNELASLQRQTEAAEKNHAEQQHKLRQESDQQAAALSEEQEKQSRSFQDQEQELRSVIGSLQAENDLLSKQLEQVRQAMEEELEKEQASEVKSQDAFKDMEQQKEEMEKRLTEKIKQLEAELHETQSSKRDEGLPLQAEGPTDAGAPLSLDSALQERLQQERASLQSQMELLEKKKNEEMQNLKTSLIAEQQTNFNTVLTREKLKKEQIINELTEELRNVTQQQEKDKALIEKLSEDRASVMQEKKHLEEELNRMRSTAMVSSAFFTPHHSARETPEAAGAAARAPPMAGAFTSEPLSETDRLASVAAIGDDEQIDSAVEASMVSVHDNLLMSEEKQRILLLERTLHMKEEENKRLSQRLMSQSMSSVSSRHSDKIAIRDFQVGDLVLIILDERHDNYVLFTVGPTLYFLHSESLTALDLKPASGTTRRPWVLGKVMEKEYCQAKKAQNRFKVPLGTKFYRVKAVPWNRKV","proteome":"UP001346869","gene":"PBY51_021583","go_terms":[{"identifier":"GO:0000045","name":"autophagosome assembly","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"1fe521c10d92d0d316906b6b0b3bab32b77ee4b9","counters":{"domain_architectures":3327,"entries":8,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"cdd":1,"pfam":2,"panther":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":3327}}}