{"metadata":{"accession":"A0AAD4KKF9","id":"A0AAD4KKF9_9EURO","source_organism":{"taxId":"1131652","scientificName":"Talaromyces proteolyticus","fullName":"Talaromyces proteolyticus"},"name":"4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase","description":["Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme"],"length":307,"sequence":"MQRFHLTATGHNINYLPQYIAERHGFFQEQGLDATFSIPQPWDGVLDDLAEGTADSALGGIWVPTMYHNRVTNYTVFAQIANRCPLALIKRGPSQDFKLADVAGATVLMKSGGGASVGLFFKMLLRENSIDPKSVDYIQDLDGVMLGNLFQGGMGDYFVTDILSARTMADRNPNVSVAMEMVSQGDVPWSVYYRETATITDEVLDKQKRFLAALAKGIDWVLQRDAESFKNELAELFPTVPVQVAVDVTNTFRHNSMWTSPLIPRGGFDRWQLGLVGARLVKDPLAYETLINDVPVLAALKAKSDQS","proteome":"UP001201262","gene":"BGW36DRAFT_362060","go_terms":[{"identifier":"GO:0009228","name":"thiamine biosynthetic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"a7843b174854e51b1f7bf70c154a1e948dc81e7c","counters":{"domain_architectures":65119,"entries":6,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"panther":1,"pfam":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":65119}}}