{"metadata":{"accession":"A0A9L0RW12","id":"A0A9L0RW12_HORSE","source_organism":{"taxId":"9796","scientificName":"Equus caballus","fullName":"Equus caballus (Horse)"},"name":"Histone-lysine N-methyltransferase 2D","description":["Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription"],"length":5528,"sequence":"MDSQKPPGEDKDSESAADGPAASEESGATEPDLPNPHVGEVSVPSSGGPRVQEPLQDCSGGPPRRCALCNCGEPSLHGQRELRRFELPFDWPRCPVVSPGGNPGPSEAALPSEDLSQIGFPEGLTPAHLGEPGGSCWAHHWCAAWSAGVWGQEGPELCGVDKAIFSGISQRCSHCTRLGASIPCRSPGCPRLYHFPCATASGSFLSMKTLQLLCPEHSEGAAHLEEARCAVCEGPGELCDLFFCTSCGHHYHGACLDTALTARKRAGWQCPECKVCQACRKPGNDSKMLVCETCDKGYHTFCLKPPMEELPAHSWKCKACRVCRACGASSAELNPNSEWFENYSLCHRCHKAQGGQPISSVAEQHPPVCSRFLPPEPGDTPTDEPDALYVACHGQPKGGHVTSMQPKEPGPLQCEAKPLGRAGAQLEPQLEAPLNEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEESPLSPPPEESPLSPPPESSPFSPLEESPFSPPQESPPSPPLETPLSPPPETSPLSPPLEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEDSPMSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDLLMSLPLEESPLSPLSEEPQLCPRPEELRLSPGSEGRHLSPASEGPCLSPRPEEPRLSPRPEEPCLSPRPEEPRLSPRPEEPCLSPAPEELHLSPQPEEPPLSPQREELHPSPQPEEPPLSPRPEELRLSPHPEELRLSPHPEELRLSPHPEELRLSPHPEELRLSPRPEETHLSPQPEEPCLSPRPEEHPEQPGLCPAPEELPLFLPPGEPPLSPLLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITAVAPPALSPLGELEYPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMILPPSPGSPMGLASPVLMEPLPPQCSPLLQDSLPPQNSLPSQCSPALPLSLPSPLSPMEKAVEVSEEAEPHEMETEKVPEPECPALEPSPTSPLSSPMGNLSCPAPSPAPALDDFSGLGEDIAPLDGTDTPGSQPEAGQTPGSLASELKGSPVLLDPEELAPVTPMEVYGPECKQAGQGSPCEEQEEPRAPVAPTPPTLIKSDIVNEISNLSQGDASASFPGSEPLLGSPDPEGGGSLSMELGVSTDVSPARDEGSLRLCTDSLPETDDSLLCDAGTAIGGGKAEGDKGRRRSSPARSRIKQGRSSSFPGRRRPRGGAHGGRGRGRARLKSTTSSVETLVVADIDSSPSKEEEDDDDDTMQNTVVLFSNTDKFVLMQDMCVVCGSFGRGAEGHLLACSQCSQCYHPYCVNSKITKVMLLKGWRCVECIVCEVCGQASDPSRLLLCDDCDISYHTYCLDPPLLTVPKGGWKCKWCVSCMQCGAASPGFHCEWQNSYTHCGPCASLVTCPICHAPYVEEDLLIQCRHCERWMHAGCESLFTEDDVEQAADEGFDCVSCQPYVVKPAAPVAPPELVPMKVKEPEPQYFRFEGVWLTETGMAVLRNLTMSPLHKRRQRRGRLGLPGEAGLEGSEPSDALGPDDKKDGDLDTDELLKGEGAVEHMECEIKLEGPISPDGEPGKEETEESKKRKRKPYRPGIGGFMVRQRKSHTRVKKGPAAQAEVLSGDGQPDEGETVMPADLPAEGSVDQSLADGDEKKKQQRRGRKKSKLEDMFPAYLQEAFFGKELLDLSRKALFAVGVGRPSFALGTPKAKGDGGSDKKELPTSQKGDDGPDVADEESRGPEGKPDTPGPEDGGVKASPVPSDPEKPGTPGEGMLSSDLDRIPTEELPKMESKDVQQLFKDVLGSEREQHLGCGTPGLDGSRTPLQRPFLQGGLSLGNLPSSSPMDSYPGLCQSPFLDSRERGGFFSPEPGEPDSPWTGSGGTTPSTPTTPTTEGEGDGLSYNQRSLQRWEKDEELGQLSTISPVLYANMNFPNLKQDYPDWSSRCKQIMKLWRKVPAADKAPYLQKAKDNRAAHRINKVQKQAESQINKQTKVGDMARKTDRPALHLRIPPQPGALGSPPPAAAPTIFIGSPTTPAGLSTSADGFLKPPAGTVPGPDSPGELFLKLPPQVPAQVPSQDPFGLAPTYALDPRFPTAPPTYPPYPSPTGAPAQPSTLGASSRPGTGQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGVGGGKASEPLLSPPPFGETRKALEVKKEELGASSPSYGPPNLGFVDSPSSGPHLGGLELKAPDVFKAPLTPRASQVEPQSPGLGLRPQEPAPAQALAPSPPSHSDIFRPGPYPDPYAQPPLTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQSRDPFAPLHKPPRPQPPEVAFKAGPLAHTPLGAGGFPAALPSGPAGELHAKVPGGQPPNFARSPGTGAFVGTPSSMRFTFPQAVGEPSLKPPVPQPGLPPPHGINSHFGPGPTLGKPQSTNFTVATGNFHPSGSPLGPSTGSTGEGYGLSPLRPPSVLPPSAPDGSLPYLSHGASQRAGITSPVDKREDPGAGMGSSLAAPELPGTQDPGMSSLSQTELEKQRQRQRLRELLIRQQIQRNTLRQEKETAAAAAGAVGTPGSWGAEPSSPAFEQLSRGQTPFTGTQDKNSLVGLPPGKLGGPILGPGAFPSDDRLSRPPPPATPSSMDVNSRQLVGGSQAFYQRAPYPGSLPLQQQQQQQLWQQQQQQQQATAATSMRLAMSARFPSAPGPELGRQALGSPLAGIPTRLPGPGEPLPGPAGPAQFIELRHNVQKGLGPGGAPFPGQGPPQRPRFYPVNEDSHRLPPEGLRGLAVSGLPPQKPSAPPAPELNNSLHPTPHTKVPTLPPGLELVSRPPSSSELGRPPPLALEAGKLSCEDPELDDDFDAHKALEDDEELAHLGLGVDVAKGDDELGTLENLETNDPHLDDLLNGDEFDLLAYTDPELDTGDKKDIFNEHLRLVESANEKAEREALLRGVEPGPLGPEERPPPAADASETRLASVLPEVKPKVEEGGRHPSPCQFTITTPKVEPAPATPSLGLGLKPGQSVMGSRDTRMGTGPFSSSGHTTEKGPFGATGGPPSHLLTPSPLSGPGGSSLLEKFELESGTLTLPGGHAASGDELDKMESSLVASELPLLIEDLLEHEKKELQKKQQLSAQLQPAQQQQQQQQQQQQHSLLATPGPTQAMSLPHEGSSPSLAAPQQQLALGLGGSRQPGLAQPLMPTQPPAHALQQRLAPSMTMVSNQGHMLSGQHGGQAGLVPQQSPQPVLTQKPMSTMPPSMCMKPQQLAMQQQLANSFFPDTDLDKFAAEDIIDPIAKAKMVALKGIKKVMAQGSIGVAPGMNRQQVSLLAQRLSGGPGSDLQNHVAAGSGQERSAGDPSQPRPNPPTFAQGVINEADQRQYEEWLFHTQQLLQMQLKVLEEQIGVHRKSRKALCAKQRTAKKAGREFPEADAEKLKLVTEQQSKIQKQLDQVRKQQKEHTNLMAEYRNKQQQQQQQQQQQQHSAVLALSPSQSPRLLTKLPGQLLPGHGLQPPQGPPGGQAGGLRLPPGGMALPGQPGGPFLNTTLAQQQQQQHSGGAGALAGPSGGFFPGNLALRGLGPDSRLLQERQLQLQQQRMQLAQKLQQQQQQQQQQQQHLLGQVAIQQQQQQGPGVQANPALGPKPQGLLPPSSHQGLLVQQLSPQPPQGPQGMLGPAQVAVLQQQQQQQQQQHHPGVLGPQGPHRQVLLNQSRVLSSPQLAQQGQGLTGHRLVTAQQQQQQHQQQGSVAGLSHLQQGLMPHSGQPKLSAQPMGSLQQQQLQQQQLQQQQQQLQQQQQQLQQQQQQLQQQQQQQQQQQQQQLQQQQLQQQQFQQQQQQQMGLLNQSRTLLSPQQQQQQQQQQQQQVTLGPGMPAKPLQRFSSPGALGPTLLLTGKEQSIVETALPPEATEGPSTHQGGPLAVATVPESVATEPGEVKPSLSGDAPLLLVQPQAQPQPNSVQLQPPLRLPGQQQQQVNLLHTAGAGSHGQPTSGSSSEASPLPHLLAQSSVSLGEQPGPMTQNLPGSQQPLGLERPMQNNAGSQPAKPGSAPQSGQGLPGTGLMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQDPGTQPSPLQGLLGRQPHLGGFPGSQTGPLQELGAGLRPQGAPRLPTPQGALSTGPVLGPVHPTPTPSSPQEPKRPSSQLPSPSSQLPSEAQLTPIQPGTPKPQGPPLELPPGKVSPASAQLADAFFGKGVGPWDPPDNLAEAHKPEQSSLVPGHLEQVNGQVAPEPPHLSIKQEPREEPCALGTQAVKREANGEPIGAPGTSNHLLLAGPRSEAGHLLLQKLLRAKNVQLSTGQGPEGLRAEINGHIDSKLAGLEQKLQGTTSNKEDTAARKPLTPKPKRVQKASDRLVSSRKKLRKEDGVRASEALLKQLKQELSLLPLTEPTITANFSLFAPFGSGCPINGQCQLRGAFGSGALPTGPDYYSQLLTKNNLSNPPTPPSSLPPTPPPSVQQKMVNGVTASEELGEHPKDAASARDTEGTLRDASEVKSLDLLAALPTPPHNQTEDVRMESDEDSDSPDSIVPASSPESILGEEAPRFPQLGSGRWEQDDRALSPVIPIIPRASIPVFPDTKPYGSLDLEAPGKLPATTWEKGKGSEVSVMLTVSAAAAKNLNGVMVAVAELLSMKIPNNYEVLLPESPARAGIEPKKGEAEGPGGKDKGLGGKSPEAGPDWLKQFDAVLPGYTLKSQLDILSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPATEPLVELPAEPSAEPPVPSPLPLASSPESARPKPRARPSEEGEDSRTPRLKKWKGVRWKRLRLLLTIQKGSGRQEDEREVAEFMEQLGTALRPDKVPRDMRRCCFCHEEGDGATDGPARLLNLDLDLWVHLNCALWSTEVYETQGGALMNVEVALHRGLLTKCSLCQRTGATSSCNRMRCPNVYHFACAIRAKCMFFKDKTMLCPMHKIKGPCEQELSSFAVFRRVYIERDEVKQIASIIQRGERLHMFRVGGLVFHAIGQLLPHQMADFHSATALYPVGYEATRIYWSLRTNNRRCCYRCSIGENNGRPEFVIKVIEQGLEDLVFTDASPQAVWNRIIEPVAAMRKEADMLRLFPKYLKGEELFGLTVHAVLRIAESLPGVESCQNYLFRYGRHPLMELPLMINPTGCARSEPKILTHYKRPHTLNSTSMSKAYQSTFTGETNTPYSKQFVHSKSSQYRRLRTEWKNNVYLARSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNRGIYMFRINNEHVIDATLTGGPARYINHSCAPNCVAEVVTFDKEDKIIIISSRRIPKGEELTYDYQFDFEDDQHKIPCHCGAWNCRKWMN","proteome":"UP000002281","gene":"KMT2D","go_terms":[{"identifier":"GO:0005634","name":"nucleus","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0042800","name":"histone H3K4 methyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0035097","name":"histone methyltransferase complex","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"5bda398aba0763c87ec8139d84177767c0d96f3d","counters":{"domain_architectures":1551,"entries":54,"isoforms":0,"proteomes":1,"sets":5,"structures":0,"taxa":1,"dbEntries":{"profile":7,"cathgene3d":4,"cdd":8,"pfam":6,"smart":7,"ssf":3,"panther":1,"interpro":18},"proteome":1,"taxonomy":1,"similar_proteins":1551}}}