{"metadata":{"accession":"A0A9F2R2F2","id":"A0A9F2R2F2_PYTBI","source_organism":{"taxId":"176946","scientificName":"Python bivittatus","fullName":"Python bivittatus (Burmese python)"},"name":"CCR4-NOT transcription complex subunit 4","description":["Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15. Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy"],"length":639,"sequence":"MSRSPDAKEDPVECPLCMEPLEIDDINFFPCTCGYQICRFCWHRIRTDENGLCPACRKPYPEDPAVYKPLSQEELQRIKNEKKQKQNERKQKISENRKHLASVRVVQKNLVFVVGLSQRLADPEVLKRPEYFGKFGKIHKVVINNSTSYAGSQGPSASAYVTYIRSEDALRAIQCVNNVVVDGRTLKASLGTTKYCSYFLKNMQCPKPDCMYLHELGDEAASFTKEEMQAGKHQEYEQKLLQELYKLNPNFLQLSTNVVDKNKNKVTSLQSSIDKPSDSLSIGNCDNSQQISNSDTPSPPPGLSKSNSVIPISSSNHSARSPFEGAITESQSLFSDNFRHPNPIPSGLPPFPSSPQTSSDWPMAPEPQSLFTSETIPVSSSTDWQAAFGFGSSKQQEDDLGFDPFDITRKALADLIEKELSVQDQPSLSPTSLQNPSPHTTTAKGSGSGFLHPATPTNANSLNSTFSVLPQRFPQFQQHRAVYNSFSFPGQATRYPWMAFPRNNIMHLNHTANPSSNSNFLDLNLPPQHSTGLGGIPIAGIPASAGNSLDSLQDDNPPHWLKSLQALTEMDGPSAAPTQTPHSNPFSTQIPLHRASWNPYSPPSNPASFHSPPPGFQTAFRPPSKPPTDLLQSSALDRH","proteome":"UP000695026","gene":"CNOT4","go_terms":[{"identifier":"GO:0003676","name":"nucleic acid binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003723","name":"RNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0046872","name":"metal ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004842","name":"ubiquitin-protein transferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0030014","name":"CCR4-NOT complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"b80063a825e18f76bedddaef7378af223444bbe2","counters":{"domain_architectures":4965,"entries":23,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"cdd":2,"profile":3,"pfam":2,"smart":1,"panther":1,"interpro":10},"proteome":1,"taxonomy":1,"similar_proteins":4965}}}