{"metadata":{"accession":"A0A8V5GRP9","id":"A0A8V5GRP9_MELUD","source_organism":{"taxId":"13146","scientificName":"Melopsittacus undulatus","fullName":"Melopsittacus undulatus (Budgerigar)"},"name":"Ryanodine receptor 1","description":["Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis"],"length":4685,"sequence":"ASKQRSEGEKVRVGDDLILVSVSSERYLHLSTASGELQVDASFMQTLWNMNPISSGGEEGYVTGGHVLRLFHGHMDECLTAAAPEQGEERSVVSYEGGAVCSQARSLWRLEPLRISWSGSHVRWAQPFRLRHVTTGRYLGLQGEQGLMLLEASAANTHVTAFCFRASKEKSEPVPRRDIEGMGPPELKYGESLCFLQHLDSGLWLTYAAADPKALRLGLLKRKAILHQEGHMDDSLSLSRSQAQEAQAARMVFSTAGLYGSFIRSLDALGSRPRSGPAPPALPLAAVELSLRDLIRYFRCPRGAELHEQRQRALRMLRARQNLFQQEGLVSLLLTCIDRLSGLSSALAERGGGEEAAAAKEVVNLLYELLASLIRGNRSNCALFCSNLDWLVGKLDRLEASSGILEVLYCVLIESPEVLNIIRENHIKSIIALLDKHGRNHKVLDVLCSLCVCDAVAVRSNQNLITENLLPRRDLLLQTGLVDRVTSIRPNVFVGTHAGSTQYPRWYYEVVLESLGCAIGTHSGVPRSVPAPQRRALTGGDVISCCLDLGVPSASFRLNGAPVHGMLEAFNLDVLYSPVVTCSAGVRLRLLLGGRQGQFRFLPPPGYSPVAQALLPRERLRLEPCKEHEGRGGPPGSRSLLGPPLPLPHTAFTPCPVDTAQIVLPPHLERVREKLAENIHELWALTRIEQGWSYGPVRDDAQRLHPCLLSFHNLPDPERSYNLQMSGETLKTLLALGCHVGMADEKAEENLRKIKLPKTYTMSNGYKPAPLDLAHVKLTPAQLTLVDRLAENSHNVWARDRVQQGWSYSTVQDIKDKRNPRLVPYNLLDENTKSRNRESLGQAVRTLLGYGYNIEPPDQDTPPGPPGVRPRLFRAERSLAVSSGRWYFEFEAVTGGPMRVGWARPHLRPDIDLGADELAFAFDGHRAQRWHVGSESFGRPWQAGDVVGCMIDLTETHISFTLNGEMLISDAGSEVAFKGFDVGEGFVPACSLPPGHWGRLNLGSVVSSLRFFTVCGLQEGFEPFGVNRKRPLPLWVSHSCPRFLPLPPEHPHIEVTRVDATPDSPPSLRLSRRAPAATPPSGAELVQLRLSLPVRFHARFRCAPPMPPGPAPPAPPPDPGTTPTAQPLPPGAPPPEAPRGGGGENEKDAATEKGKTRRGFLFKGRKVPFSPPPTAPSVPRLEQDVVPAERDDPDVIRDSTTHYFSVRLPAGQDPSCAWVGWVTPGFQQHEVTFDLSRVRSVTVTLGDSQGHVHRSIKHSDCYMVWGGDLVIGQPNRVSHTDLVIGCLVDLATGLLSFMVNGTEISTFFQVEPNTKLFPAAFVVPTSQNFLQFELGKLKNILPLSAALFSSEQGNPETMDILELWEDPSLQRFQHHTLRLYRAVCALGNTRVAHALCSHVDQAQLLFSIACTELPGPLRCGYYDLLLAMHLDAPRRAMSAMSAEFIVPVTDDAARVALSAGGTRVPGVARGVCLRPRPRFAEPCFILAPGNGHNQLSPWIPLGELGARAIGMLAEAVEGAGPSVRDPIGGSVEFELVPVLKLVSALLELGALEDEEVRKVLRMIEPRVFGEGKEEEEEEEERRRKAIEAGEEEEEEEEKEEEEKEEEEEKEKGEEEEKEEDEGPQEGLLQMKLPESVKLQMCELLQFFCSRELQHRVESLVWFAAQHVQRLQRDQRRRYQRLMQALTMSAAETARRTREFRSPPQEQVNMLLHYKDGLDEEECPVPEDIRDELQEFHNNLLAHCGIQLPQEEEEEEEDASLGQRLLGLVHRVLGRGGGHKEEEQPPPPPRGTLISQTMVHWAQESFIQSPELVRSMFSLLHRQYDALGELVRALPRAYALSARSVPDAIALLESLSQIRSLLIVQMGPEEEDLLIQSIGNIMNNKVFYQHPNLMRALGMHETVMQVMVSVLGGGESKEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLGYLLENSSIGLGMRGSTPLDVAAASVIDNNELALALKEQDLEKVVSYLAGCGLQSCPMLLAKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRRPECFGPALRGEGGAGLLAAIEEAMGTAQDPARDGPSGRRERRRELFGPEEPPEEGRVHLGNAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPLEDLVGIISLPLQLPCIGKDGSVLEPRLAAGFAPEHKAPMVLFLDRVYGVSSQELLLRVLDVGFLPDLRAAASLDTATFSTTEMALALNRYLCQAVLPLLTKCARLFAGSQHRAGLVDSALHTVYRLSRARALTKAQRDTIDEGLMALCRYIHPSMLQHLLRRLVFDVPILNEFSKMPLKLLTNHYERCWKYYCLPSGWPNHGVSSEEELHLTRKLFWGIFQSLAHKRFDPELSRLAMPCLCAIAGALPPDYADASYSSRTDKKAAVDAEGNFDPKPVETLNVIIPEKLDSFINKYAEFTHEKWAFEKVQSNWTFGETVDEEAKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMLAWEWTVEKAREEEEKVEKKKSRKISQSAQATYDPSHGYSPQPVDLSGVTLSRELQAMAEQLAENYHNTWGRKKKLELEAKGGGSHPLLVPYDTLTAQEKARDREKAQELLKFLQLQGYAVTRGLKDLELDTSSIEKRFAFGFLQQLLKWMDTSQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKVLLPLINRYFHNHCGYFLSTPALALGTGGHASNKEKEMVTSLFCKLAALVRHRVSLFGTDAPAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFEGAAEDMEKLVENLRLGKVSGGKRQVKGVAQNLSYTGAALLPVLSSLFQHLGQLRCGDDVILDDVQVSCYRILSSIYSLGTTKNPYVERQRPALGECLARLAAAMPVAFLEPHLNHLNPCSVYSTKSARERAGERRSRAAPSPLVLGLPSRVQDLCPDLPSLDHLMGDIGALAESGARYTEMPHVIEVTLPMLCSYLPRWWERGPEARPEGPCATAVTGAHLNTLLGNILRIVVNNLVFAQPIVSKAKPQLLRSHFIPTMEKLKKRAGKVVAEEEQLRMEARGEGEETELLIRDEFSVLCRDLYALYPLLIRYVDNSRAQWLTEPNEDAEELFRMVGEVFIYWSKSHNFKREEQNFVVQNEINNMSFLTADSKSKMAKGGSAPERSQAPRRGDRYSVHTSLIVATLKKLLPIGLNLCSPADQELIALAKGRYAMKDTDEEVREFLTNNLHLQGKGQNSASLRWQMMLFRSLAGRAADAQSPERVVRRVQEVAAVLYHLEQTEHSYKSKRAVWHKLLSKQRRRAVVACFRMAPLYNLPRHRACNLFLEAYRLQWLQPQEHPFEDRMIDDLAASGQEEEEEEEEEEKKPDPLHQLILHFSRTALTEGSKLESDHLYMAYAGIMAKSCHIEEEEEEEEEEQEEEEAEDSFEEKELEKQKLRYQQGRLHERGAAEMVLQMLSACKGERGSMVSSTLKLGISILNGGNAEVQQKMLDYLKEKREVGFFQSLQALMQTCSVLDLNAFERQNKAMGLGMVAEDGTISRDNGEKVMADDEFTQDLFRLLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKEVIDEHGKRNFSKAMAVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVIGFLHVFAHMMKKLAQHSSQIGLLKELLDLQKDMVVMLLSLLEGNVVNGTIARQMVDMLVESSSNVTMILKFFDTFLKLRDIVSSDAFRASITDPRGLMSKKDFQRAMDNQKQLEPSEIQFLLSCSEADENDMIDVDSFACRFQEPARDIGFNVAVLLTNLSEHVPHDQRLHTFLEHASSILEYFRPFLGRIEVMGSARRIERLYFEISAANKAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIASRLSEDGTAAPETDDGSDDGDDDGGEASAEARPRWSRVLALCRRRLRQWRRRPCRELARAAGGGLGRALWGAAGAGCGAVSAMGRVLWGAVFGGGLVEGAQRLALAEVLAGMPDPTQDAVGGAAVGGEGEDGGGPIEELGPIEEAQEEKEEEEEEEEEEEGKGKAMPLVPLGGQKEHPRLAALEATVGGLGDIGEPPGAEPPTPEGSPILRRKGGVCVGHTENGEKGGAEGGPDPVPPKRRRSVPKARKEPPSDGAFEVWGELEVQRVKFLNYLSRNFYNLRFLALFLAFAINFILLFYRVSEHPPGTEEGEEGSGGGAMAEEGAEPEEAPPIHYVLEEGTGYMQPALRALALAHTLVAFLCIIGYNCLKIPLVIFKREKELARSLEFSGLYISEQPPDDDVKGQWDRLVLNAQSFPRNYWDKFVKRKVLDKYGAIYGRERIAELLGMDLDSLEIGARGERRPPPDSSFITWVAAIDVRYQIWKFGVIFTDNSFLYLTWYMVMSLLGHYNNFFFASHLLDIAMGVKTLRTILSSVTHNGKQQVWGSYGSLCLTMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG","proteome":"UP000694405","gene":"LOC115945910","go_terms":[{"identifier":"GO:0005262","name":"calcium channel activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0070588","name":"calcium ion transmembrane transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006816","name":"calcium ion transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005219","name":"ryanodine-sensitive calcium-release channel activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006874","name":"intracellular calcium ion homeostasis","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005216","name":"monoatomic ion channel activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006811","name":"monoatomic ion transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0055085","name":"transmembrane transport","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"da17a23f1a8abd482be628629cdaf4f44be746e2","counters":{"domain_architectures":7,"entries":46,"isoforms":0,"proteomes":1,"sets":5,"structures":0,"taxa":1,"dbEntries":{"pfam":9,"cathgene3d":6,"smart":2,"profile":2,"ssf":4,"cdd":2,"panther":1,"prints":1,"interpro":19},"proteome":1,"taxonomy":1,"similar_proteins":7}}}