{"metadata":{"accession":"A0A8R2M7D8","id":"A0A8R2M7D8_BOMMO","source_organism":{"taxId":"7091","scientificName":"Bombyx mori","fullName":"Bombyx mori (Silk moth)"},"name":"RNA helicase aquarius","description":["Involved in pre-mRNA splicing as component of the spliceosome. Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro)"],"length":1145,"sequence":"MYSKKKKPVYLLLQMLKFYARFEISDQTGDPMTDRDMTLQHYSKITSLQKAAFSKFPDLRLFALANVASVDTRETLQKHFKNLSDKALRAIATYLNLVPPEGKEDETPWHRLDKDFLRELLISRHERRISQLEELNLMPLYPTEEIIWDENVVPTEIYSGENCLALPKLNLQFLTLHDYLLRNFNLFRLESTYEIRQDIEDAVYRLAPWNSEDGSVYFGGWARMAHPIKSFAVVEVAKPNIGEKAPSRVRADVTVTLSLRNEIKHEWENLRKHDVCFLVTVRPTQGIGTKYDYRKSMVDQAGIVYVRGCEVEGMLDASGRVIEDGPEPRPELEGDSRTFRLLLDPNQYRLDLDRASKGNEDVYETFNIVMRRKPKENNFKAVLETIRELMNTECVVPDWLHDIVLGYGDPGQAHYTRMPNEIATLDFNDTFLNMDHLRNSFPGYEIKVQTNDPRKLVRPFKLTFENVVRKQQVGDAAMDEDEPRKAIIVEPHVQPKRGPYLYNEPKKNNILFTPTQVEAIRSGMQPGLTLVVGPPGTGKTDVAVQIISNIYHNFPWQRTLVVTHSNQALNQLFEKVAELDVDERHLLRLGHGEEALQTDKDFSRYGRVNYVLAKRLELLELVSRLQRTLDAGSDAGATCELAHHFHVYHVRPRWRAFLENCQQQTNSIEIVSKEFPFHEFFDDAPKPLFLRKSHEEDMEIAKSCYRYIDHIFEELEEFRAFELLRSGLDRSKYLLVKEAKIIAMTCTHAALKRSELVQMGFKYDNILMEESAQILEIETFIPLLLQNPQDGRSRLKRWIMIGDHHQLPPVVKNMAFQKYCNMEQSLFTRMVRLGVPYVELDAQGRARPSICNLYRWRYRALGDLCHVTQLPEYRAANAGLRHDFQLVNVDDFNGVGETEPSPYFYQNLAEAEYVVAVFMYMRLIGWPAERISILTTYNGQKHLIRDVIDKRCADNPLIGRPHKVTTVDKYQGQQNDIALVSLVRTKAVGHVRDLRRLIVAASRARLGLYIFARANLFRNCYELQPTFNQLVERPLQLELVPGERYPAQRAAGVAVPPELLLSVRDMPHMARYVYDMYLHIVNDAPDARQESGWRAPGGREAARARGAGGHVPAHPGAAPDSDDESDAFTPTDILNEVDEPNAANS","proteome":"UP000005204","gene":null,"go_terms":[{"identifier":"GO:0004386","name":"helicase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"29e918d769405353fa83a58b5be30c6e6d14eff1","counters":{"domain_architectures":3141,"entries":18,"isoforms":0,"proteomes":1,"sets":5,"structures":0,"taxa":1,"dbEntries":{"pfam":5,"cathgene3d":1,"ssf":1,"cdd":2,"panther":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":3141}}}