{"metadata":{"accession":"A0A8N5ERE0","id":"A0A8N5ERE0_GEOFO","source_organism":{"taxId":"48883","scientificName":"Geospiza fortis","fullName":"Geospiza fortis (Medium ground-finch)"},"name":"Huntingtin-interacting protein 1","description":["Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Regulates presynaptic nerve terminal activity. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors"],"length":1026,"sequence":"MPEQGLCKKSIVVMPLDSSMAHGACCSQVFLLAPFSEAPVTAGLLSSFPETVSINKAINAQEVAVKEKHARTCILGTHHEKGAQTFWSVVNRLPLSGNAVLCWKFCHVFHKLLRDGHSNVLKDSVRYKNELSDMSRMWGHLSEGYGQLCSIYLKLLRTKMEFHTKNPRFPGNLQMSDRQLDEAGENDVNNFFQLTVEMFDYLECELNLFQTVFSSLDMSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTVKLLFKLHSCLPADTLQGHRDRFLEQFRKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEASSPDSEPITDLVEMDAASQSLFDNKFDDIFGSSFSCDPFNFNSQNGMNKDDKDRLIEQLYGEITALKEELENFKAESARGAVQLRGRASELEAELAEQQHLKQQAQDESEFLRAELEELKKQREDTEKAQRSLTEIERRAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQITVARQAQGDVEQEKKELEDSFQRMTEQAQRKSQEQAEVLETLKRELAASRQELQVLQGTLESSTQAGVEQNTRIASLEQERDRLSQAAEQHRDKMAALQAELQQLRDTLSHEQESTELALQQRLAEEQLSLLQSTTREAEHMVQDALARMEDPAHISCTGSAGDAPVASAMGAEACAHCPAAAVGSLLPHLALFAHLVSNTLLQGSATSHVAPVEPADRLLELCKQCGSETVSYLSALQDPGKVASADCSLVTACLGQISAIGEELRPRGLDIKQEELGDLVDKEMAATAAAIEIASARIEEMLSKARAGDTGVQLEVNERILGSCTGLMQAIRVLVLASKDLQREIVESGRGAASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGKGTFEELMVCSREIAASTAQLVAASKVKADKDSANLCKLQQASRGVNQATASVVASTKAGKSQVEEKDSMNFSSMTLTQIKCQEMDSQVRVLELENQLQKERQKLGELRKKHYELAGVAEGWEEDAAD","proteome":"UP000504602","gene":"HIP1","go_terms":[{"identifier":"GO:0005543","name":"phospholipid binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003779","name":"actin binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0030276","name":"clathrin binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006897","name":"endocytosis","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"852be214f92d2c7bfe849e76fb82a5b7047cde6f","counters":{"domain_architectures":2207,"entries":23,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"profile":2,"cathgene3d":4,"smart":2,"pfam":4,"ssf":2,"panther":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":2207}}}