{"metadata":{"accession":"A0A8M2B860","id":"A0A8M2B860_DANRE","source_organism":{"taxId":"7955","scientificName":"Danio rerio","fullName":"Danio rerio (Zebrafish)"},"name":"S-phase kinase-associated protein 2","description":["Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, NBN, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration. Following phosphorylation in response to DNA damage, mediates 'Lys-63'-linked ubiquitination of NBN, promoting ATM recruitment to DNA damage sites and DNA repair via homologous recombination"],"length":427,"sequence":"MCCWRAPDVLLGRARIHLLHKSVFQELSENLEGSLCRSQRTKWKKRPSCSSGLDTENTPNELIQQWSPPHKKALTTAKGKENEENLFVLARRPRKRRESSANLCWDSLPDELLLGIFSRLSLQDLLRTSRVCKRWHRLAFDESLWHSVDLVGKAQLDAELGQVLSAGVLRLRCPHTCIGQPSFKSTPSLRVQHLDFSNCTVETSVLEDVLSRCKHLQNLSLEGLVLSDNIIYSLAQNPEIIRLNLCGCSGFSPESLTEMLTACTRIEEMNVSWCDFSNLHIQAIASNIPSSVSQLNISGYRQNLTMEDVKAIVKRCPNITDLDLSDSVLVTTDSFPVLQQLSSLRHLGLSRCYQIHPASLIDFEKFLNLQTLEVFGLIQDSYLPILCKSLPHIQINTQPFSTVARPTSSSRKDRTLWGMHCRLVYKH","proteome":"UP000000437","gene":"skp2","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"3ebb2b79836e06012b0d65e4592940f278ad23bf","counters":{"domain_architectures":93656,"entries":13,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":2,"cathgene3d":1,"profile":1,"cdd":1,"pfam":1,"smart":2,"panther":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":93656}}}