{"metadata":{"accession":"A0A8L2Q513","id":"A0A8L2Q513_RAT","source_organism":{"taxId":"10116","scientificName":"Rattus norvegicus","fullName":"Rattus norvegicus (Rat)"},"name":"Pyruvate dehydrogenase E1 component subunit beta","description":["The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2","Together with PDHA1 forms the heterotetrameric E1 subunit of the pyruvate dehydrogenase (PDH) complex. The PDH complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). The E1 subunit catalyzes both the thiamine pyrophosphate (TPP)-dependent decarboxylation of pyruvate and the reductive acetylation of a lipoyl group covalently linked to the lipoyl-bearing domains of E2"],"length":395,"sequence":"MAAVAGLVRGPLRQASGLLKRRFHRSAPAAVQLTVREAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSAGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDDNPVVMLENELMYGVAFELPTEAQSKDFLIPIGKAKIERQGTHITVVAHSRPVGHCLEAAAVLSKEGIECEVSWGNGSSSKGLLCKHEDLSWSPSTHIKTKPEQTSQVINLRTIRPMDIEAIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI","proteome":"UP000002494","gene":"Pdhb","go_terms":[{"identifier":"GO:0004739","name":"pyruvate dehydrogenase (acetyl-transferring) activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006086","name":"pyruvate decarboxylation to acetyl-CoA","category":{"code":"P","name":"biological_process"}}],"protein_evidence":1,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"e04a46a45c62b0dadb38c5ce19b8d26486639565","counters":{"domain_architectures":21,"entries":15,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"pfam":2,"cathgene3d":2,"smart":1,"ssf":2,"cdd":1,"panther":1,"ncbifam":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":21}}}