{"metadata":{"accession":"A0A8J0VA21","id":"A0A8J0VA21_XENLA","source_organism":{"taxId":"8355","scientificName":"Xenopus laevis","fullName":"Xenopus laevis (African clawed frog)"},"name":"MAP kinase-activating death domain protein","description":["Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family. Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion. Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction. Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses. Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals. Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2. May link TNFRSF1A with MAP kinase activation. May be involved in the regulation of TNFA-induced apoptosis"],"length":1639,"sequence":"MGQRKKPCPRLLDYLVIVGARQPSSDSISQTPELLRRYPLEDHPEFPLPPDVVFFCQPEGCLSVRQKRMSLRDDMSFVFTLTDKDSGVIRYGICVNFYRSFQKRLPKDKSRKPPKPASENGSEGSDGGHPMQPHSAESTPDINRSPRGKRLSKGTQRSRNSTLTSLCIISYYPFFSTFRECLYTLKRLVDCCSERLVSKKAGITKGVQRDTMWRIFTGSLQLEEKPNVLLHDLREIEAWIYRLLRSPTPVPGQKRVDVEVLPLDHQPPLTFALPEPSRFSLVDFPLHLPLELLGVEACLQVLSCIMLEHKVVLQSRDYNALSMSVMAFVSMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKSDFKMPDDVWLVDLDTNKVVAPTNAELLPVLPEPEASELKKHLKQALASMSLNTQPILNLDRFHEGADAALLKAPNDAQGTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSPNMLHNFQMHTRTLRLFPRPVVAFQASSFLAARPKPSHFTEKLSKTQAVEFFGEWSLNPTNFAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDANSQLAEAFSVPAERDSDSDPTDDSGSDSVEYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAALGDASEVEFDDFQEYSGEIEENNGDSENSPDNNQPRSGSSTTDSSSPSTVIHGANTESADSAEPEDKVMGVLQNHLPVLPPTFTRIAMERRENDVSLGGGEARKREYDNPYFEPQYGFPLEEETEDREESYTPMFNQSVNGNRSPKPLLRPNSLKLASDSDAETDSRGSSPTSTVSNNSGNNEGFGGIMSFASNLYKTHSSSFSLSSLTLPSKSRDKATPFPSLKVFGLNTIMEIIADSGPAPAEGSNRRALVDQKSSGIKHSPTVKRESPSPQGKSNNSSENQQFLKEVALGVLEGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRSIQTEEDARNDVIQEVEISRKVYRGMLDLLKCTVSSLEQTYANAGLGGMASVFGLLEIAHSHYYNKEPEKRKHSPSADGAVTPVSRDPVSALRVESRPAPQLPAKQLLPRPSGPAGRGPREFDTRSLKEENFVASIELWNTHREVKKQKAMDKQSTKPVLPVVDSGETEEKKSQISADSGLSVTSGSQRSDLDTSSVGPSILIRSSSQDSEISTVVSNSSGETLGADSDLSSNAGDAQGGPGGSHLSGSGAVSDSEIQMNSFTGAVFAKPQMLRPGERERNVSPGRPQQDLSQRIYLYEGLLGRDKGSVWDQLEDAAMETFSLSKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYFSLGDHDRKRLEEDEDRLLGTLLHNMISYMIMMKVNKTDLRRKVRRILGKCHIGLVHSQQINELLDKVTDMNARDLSVRPSGSRHIKKQTFVVHAGTDTSGDLFFMEVCDDCIILRSNIGAVYERWWYEKLINMTYCPKTKVLCLWRRNGQETQLNKFFTKKCRELYYCVKESMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINLKFMHSQVFIQLNHIKKCNTVRGVFVLEEFVPETKEVVSHKYKTPMAHEICYSVLCLFSYMAAIRGKEAELKSRPPRPVSS","proteome":"UP000186698","gene":"madd.S","go_terms":null,"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"1661a65e43513d6ed0ca85f9f744b57acf95d6a6","counters":{"domain_architectures":4907,"entries":21,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"smart":3,"profile":1,"pfam":5,"panther":1,"interpro":9},"proteome":1,"taxonomy":1,"similar_proteins":4907}}}