{"metadata":{"accession":"A0A8J0U749","id":"A0A8J0U749_XENLA","source_organism":{"taxId":"8355","scientificName":"Xenopus laevis","fullName":"Xenopus laevis (African clawed frog)"},"name":"Translation initiation factor eIF2B subunit alpha","description":["Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed"],"length":255,"sequence":"MNEEEIVQYFKCQLQEDTNVATAVAAIKTLLEFLKRDTGKDYDKCKKMMSERGELFLKRISMSRNKITTLCCPFIKDGAKILTHAYSKVVLKVLEEAAASKNFSVYVTESQPDLSGKIMAEALRNRNVPVTLILDAAVGYIMEKVDLVIVGAEGVVESGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQRDVPDKFKYKADTQQQDLLEEHPWIDYTSPSLITMLFTDLGVLTPSAISDELIKLYL","proteome":"UP000186698","gene":"eif2b1.S","go_terms":null,"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"22494587f6b739b485007c3a0a6eb4fbe55754ab","counters":{"domain_architectures":30139,"entries":10,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":1,"pfam":1,"panther":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":30139}}}