{"metadata":{"accession":"A0A8H4PRE1","id":"A0A8H4PRE1_9HYPO","source_organism":{"taxId":"72228","scientificName":"Ophiocordyceps sinensis","fullName":"Ophiocordyceps sinensis"},"name":"Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial","description":["Short and branched chain specific acyl-CoA dehydrogenase that catalyzes the proR-proR stereospecific alpha,beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). Among the different mitochondrial acyl-CoA dehydrogenases, acts specifically on short and branched chain acyl-CoA derivatives such as (S)-2-methylbutyryl-CoA as well as short straight chain acyl-CoAs such as butyryl-CoA (butanoyl-CoA). Plays an important role in the metabolism of L-isoleucine by catalyzing the dehydrogenation of 2-methylbutyryl-CoA, one of the steps of the L-isoleucine catabolic pathway. Can also act on valproyl-CoA, a metabolite of valproic acid, an antiepileptic drug"],"length":447,"sequence":"MSSSWLARMVRPALGGGRGLAQGAIKARSTAVRGPIKITRPLSSTASPRSSSAPPLDISDVPPTPISHLSEVETAMADAVSRFARQVVLPRARDMDEAEQMDPAIVEQLFEQGLMGVEIPDEYGGAGMNFTAAIVAIEELARVDPSVSVLVDVHNTLCNTAILNYASPALKKKWLPRLATDTVASFCLSEPVSGSDAFALATRAVETPDGFRISGSKMWITNSVEANLFIVFANLDPPKGYRGITAFLVEKGTKGFSIAKKEKKLGIRASSTCVLNFDDVDVPKENLLGERGHGYKYAISLLNEGRIGIAAQMTGLALGAFDNAVRYVWNDRKQFGSLVGEFQGMQHQIAQSYTEIAAARALVYNAARRKEAGQDFVKDAAMAKLYTSQVACRVSGLAIEWMGGMGFVREGLAEKYWRDSKIGAIYEGTSNIQLNTIAKLLQKEYTN","proteome":"UP000557566","gene":"G6O67_005385","go_terms":[{"identifier":"GO:0016627","name":"oxidoreductase activity, acting on the CH-CH group of donors","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0050660","name":"flavin adenine dinucleotide binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003995","name":"acyl-CoA dehydrogenase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"c9fd574aecd15169638af0612dc6d2bb4a1db62a","counters":{"domain_architectures":156641,"entries":20,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"ssf":2,"pfam":3,"cdd":1,"panther":1,"prosite":2,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":156641}}}