{"metadata":{"accession":"A0A8C9KL39","id":"A0A8C9KL39_PANTA","source_organism":{"taxId":"74533","scientificName":"Panthera tigris altaica","fullName":"Panthera tigris altaica (Siberian tiger)"},"name":"Adhesion G-protein coupled receptor G6","description":["Adhesion G-protein coupled receptor (aGPCR) for steroid hormones, such as progesterone and 17alpha-hydroxyprogesterone (17OHP). Involved in many biological processes, such as myelination, sprouting angiogenesis, placenta, ear and cartilage development. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRG6 is coupled to G(i) G alpha proteins and mediates inhibition of adenylate cyclase. Also able to couple to G(q) G proteins. Involved in myelination of the peripheral nervous system: required for differentiation of promyelinating Schwann cells and for normal myelination of axons. Also acts as a regulator of body length and bone mass. Acts as a regulator of blood-brain barrier formation in the central nervous system vie its association with LRP1 and ITGB1"],"length":1250,"sequence":"MMIHSDQMWNCRWKWKPGSLPFFIALCLVYVPLSVWGCANCRVILSNPSGTFTSPCYPNDYPNSQACMWTLRAPTGYIIQITFNDFDIEEAPNCIYDSLSLDNGESQTKFCGATAKGLSFNSSANEMHVSFSSDFSIQKKGFNASYIRVAVSLRNQKVILPQTLDSYQVSVAKSVSIPELSAFTLCFEATKIGKEDHEWTAFSYSNASSTQLFGFGRAKSGYFLSISGSKCFLNSVLPVKDKEDIFTESFEQLCITWNNSLGFIGVNFKRNYEAVPCDSTINKVIPGNGKLLLGSSDNEIASLKGDIYNFRLWNFTMNSKILSNLSCNVKGNVVDWQNDFWNIPTLALKAESNLSCGSYLIPLPATELANCADLGTLCQATVDSPSTTPPTVTTNMPVTNRIDKQRNDGIIFRISIVIQNILHHPEVKVQNKVAEWLNFSFQNWNYTVYVVNISFHLSTGEDKIKVKRSIGNDPRLVIWALLVYNATNNPNLEGKDIQQKLLKNNESLDEGLRLYAVSVKQLGLCYADEDPKGYQWPLIPPSVYNFPCPGKQGFYASRTCYRDLANTSLAYWGPPDISNCSREANEVANQILNLTGDGQTLSSANITSIVEQVKRIVNKEENIDIMLGSTLMNIFSNILTSPDSDLLESSSEALKTIDELAFKIDLNSTSRVNITTRNLALGVSSLSPGTNEISNFSIGLPSNNESYFQMDFESGQTDPLASVILPPNLLENLSQEDSLLVKRAQFTFFNKTGLFQDVETKKGTLVSYVMACSIGNITIQGLKDPVRIKIKHTRNQAVPHPICAFWDLNKNEGSGFWNTSGCVAHRGSDESETVCLCNHLTHFGVLMDLQGTASQIDATNTKVLTFITYIGCGISAIFSAATLLTYVAFEKLRRDYPSKILMNLSTALLLLNLLFLLDGWITSFHVEGLCMAVAVLLHFFLLATFTWMGLEAIHMYIALVKVFNTYIRRYILKFCIIGWGLPALIVSIVLASKNQNEVYGKESYGKEQGDEFCWIQDPVIFYVTCAGYFGVMFFLNVAMFIVVMVQICGRNGKRSNRTLREEVLRNLRSVVSLTFLLGMTWGFAFFAWGPLNVPFMYLFSIFNSLQGLFIFIFHCAMKENVQKQWRRHLCCGRFRLADNSDWSKTATNIIKKSSDNLGKSLSSSSIGSNSTYLTSKSKSSSTTYFKRNSHTDNASMNKSLSKLTHADGEQTSIIPVHQVIDKVKGYCNAHSDNFYKNIIMSDTFSHSTKF","proteome":"UP000675900","gene":"ADGRG6","go_terms":[{"identifier":"GO:0004930","name":"G protein-coupled receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007186","name":"G protein-coupled receptor signaling pathway","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0004888","name":"transmembrane signaling receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007166","name":"cell surface receptor signaling pathway","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"7fdecae750ec64943058f49773ea0a33d651b8fc","counters":{"domain_architectures":1232,"entries":36,"isoforms":0,"proteomes":1,"sets":5,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":4,"pfam":6,"smart":3,"profile":4,"cdd":1,"ssf":3,"panther":1,"prosite":1,"prints":1,"interpro":12},"proteome":1,"taxonomy":1,"similar_proteins":1232}}}