{"metadata":{"accession":"A0A8C9EGA9","id":"A0A8C9EGA9_PHOSS","source_organism":{"taxId":"42100","scientificName":"Phocoena sinus","fullName":"Phocoena sinus (Vaquita)"},"name":"DNA replication licensing factor MCM2","description":["Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division. Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis"],"length":904,"sequence":"MAESSESFTVASSPAPRRRGNDPLTSSPGRSSRRTDALTSSPGRDLPPFEDESEGLLGTEGPLEEEEEDGEELFGDGMERDYRPIPEIDVYEPEGLAPDDEDVDELTASQREAAERVMRQRDREAGRGLGRMRRGLLYDSDEEEEEERRSRKRRQVERATEDGGEADEMIESIENLEDLKGHSVREWVSMAGPRLEIHHRFKNFLRTHVDGRGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQIFSEAALEVVLAMYPKYDRIASRVHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCNKCGFVLGPFCQSQNQEVKPGSCPECQSAGPFEVNMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGALNTANGFPVFATVILANHVAKKDNKVAVGELTDEDVKKIISLSKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWALEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDVLCVVRDTVDPVQDEMLARFVVGSHIRHHPSNKEDGGLGGAPEPPMPNTYGVEPLPQEVLKKYIIYAKEKVHPKLNQMDQDKVAKMYSDLRKESMATGSIPITVRHIESMIRMAEAHARIHLRDYVMEDDVNMAIRVMLESFVDTQKFSVMRSMRKTFARYLSFRRDNNELLLFILKQLVAEQVTYQRNRFGAQQDTIEVPEKDLVDKARQIHIHSLSAFYDSELFRMHRFTHDLKRKMILQQF","proteome":"UP000694554","gene":"MCM2","go_terms":[{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006260","name":"DNA replication","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0006270","name":"DNA replication initiation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005634","name":"nucleus","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0042555","name":"MCM complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"dda34b973f147f7b0258b18ffb50627830303092","counters":{"domain_architectures":2610,"entries":30,"isoforms":0,"proteomes":1,"sets":6,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":4,"pfam":6,"ssf":2,"smart":1,"profile":1,"cdd":1,"panther":1,"prosite":1,"prints":2,"interpro":11},"proteome":1,"taxonomy":1,"similar_proteins":2610}}}