{"metadata":{"accession":"A0A8C7JE96","id":"A0A8C7JE96_ONCKI","source_organism":{"taxId":"8019","scientificName":"Oncorhynchus kisutch","fullName":"Oncorhynchus kisutch (Coho salmon)"},"name":"Alpha-1B adrenergic receptor","description":["Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C. ADRA1B binds the catecholamine ligands norepinephrine and epinephrine. Can also couple to G(14) and G(16) proteins. Nuclear ADRA1B forms heterooligomers with ADRA1A to regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. At the plasma membrane, ADRA1B interacts with CAVIN4/MURC to regulates ERK activation in cardiomyocytes, contributing to the regulation of cardiac hypertrophy"],"length":500,"sequence":"MSFDTANDANFWSNGSSELYAETPGPLSANNSNLTTANYTDTNPLDLTRAVSVGMVLGAFILFAIVGNILVILSVVCNRHLRIPTNYFIINLAIADLLLGTTVLPVSATLEILDYWVFGRIFCDIWAAVDVLCCTASIMSLCVISIDRYIGVRYPLQYPCIVTEKRAILAMLGVWVLATVISIGPLLGWKQPPSNDDTVCPITEEPFYALFSSLGSFYIPLAVILCMYCQVYVVAKRTTKNLEAGVMKERMDSNELTLRIHCKNAQLQEYCVTGKGQARSTLTVKLLKFSREKKAAKTLGVVVGMFILCWLPFFLVLPIGSFNANLRPSETFFKVIFWLGYFNSCLNPIIYPCYSREFKQAFIRILKCRCHQKKKKQKGWNAYYNQRSSRLGSTNTSYLNGSQQTLSSVNPSPHCVSKGTGSRLEPGFDLNSPSPCTSLPGSPFTGQMRALPGAVYQSTSRNNRVHLVSPLARESVHANGQSRNGEVEHGTIRATPDTIM","proteome":"UP000694557","gene":"ADRA1B","go_terms":[{"identifier":"GO:0004937","name":"alpha1-adrenergic receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006937","name":"regulation of muscle contraction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0007186","name":"G protein-coupled receptor signaling pathway","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0019229","name":"regulation of vasoconstriction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0055117","name":"regulation of cardiac muscle contraction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0004930","name":"G protein-coupled receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004935","name":"adrenergic receptor activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"587fa3dbe4504dc051049f3cca904dd9ab631b87","counters":{"domain_architectures":340674,"entries":14,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"cdd":1,"smart":1,"pfam":1,"profile":1,"panther":1,"prosite":1,"prints":2,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":340674}}}