{"metadata":{"accession":"A0A8C6F7G4","id":"A0A8C6F7G4_MONMO","source_organism":{"taxId":"40151","scientificName":"Monodon monoceros","fullName":"Monodon monoceros (Narwhal)"},"name":"Alpha-synuclein","description":["Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity"],"length":125,"sequence":"MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAEKTKEGVLYVVAEKTKEQVTNVGEAVVTGVTAVAQKTVEGAGSIAAATGFGKKDQLGKSEGASQEGILEDTPVDPDNEAYEMPSEEGYQDYEPEA","proteome":"UP000694561","gene":"SNCA","go_terms":[{"identifier":"GO:0014059","name":"regulation of dopamine secretion","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005737","name":"cytoplasm","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"ba377935bbbad4e8c0f939864858b21a58ebc159","counters":{"domain_architectures":3377,"entries":8,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"panther":1,"pfam":1,"prints":2,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":3377}}}