{"metadata":{"accession":"A0A8C2T8I7","id":"A0A8C2T8I7_COTJA","source_organism":{"taxId":"93934","scientificName":"Coturnix japonica","fullName":"Coturnix japonica (Japanese quail)"},"name":"Collectin-11","description":["Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding. Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis"],"length":271,"sequence":"MKRDLVFLVTLISLAFLSLLRSGYPQHIAEESCSVQILVPGLKGEAGEKGEKGAPGRPGRVGPPGEKGEMGDKGQKGSMGRHGKIGPIGSKGEKGDNGDIGPPGPNGDPGIPCECSQLRKAIGEMDIQVAQLTTELKFIKNAVAGVRETDNKIYLLVKEEKRYKEAQLYCHGRGGTLSMPKDENANNLIASYINQAGLTRVFIGINDLEKEGNYVYSDRSPMQTFNKWRSGEPNNAYDEEDCVEMVASGGWNDVACHITMYFVCEFDKENV","proteome":"UP000694412","gene":"COLEC11","go_terms":null,"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"b625bbf60511957b4004441b636cccc6a6bd9776","counters":{"domain_architectures":2652,"entries":16,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"pfam":2,"cathgene3d":1,"smart":1,"ssf":1,"profile":1,"cdd":1,"panther":1,"prosite":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":2652}}}