{"metadata":{"accession":"A0A8C2M8T3","id":"A0A8C2M8T3_CRIGR","source_organism":{"taxId":"10029","scientificName":"Cricetulus griseus","fullName":"Cricetulus griseus (Chinese hamster)"},"name":"Chloride intracellular channel protein","description":["In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3"],"length":253,"sequence":"MALSMPLNGLKEEDKEPLIELFVKAGSDGESIGNCPFSQRLFMILWLKGVVFSVTTVDLKRKPADLQNLAPGTHPPFITFNSEVKTDVNKIEEFLEEVLCPPKYLKLSPKHPESNTAGMDIFAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLPDEIDENSMEDIKFSTRRFLDGDEMTLADCNLLPKLHIVKVVAKKYRNFDIPKGMTGIWRYLTNAYSRDEFTNTCPSDKEVEIAYSDVAKRLTK","proteome":"UP001108280","gene":"Clic4","go_terms":null,"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"6ee8c40b3cf300cf9d57d5dff4dee7903c9063ed","counters":{"domain_architectures":3924,"entries":19,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"cdd":1,"pfam":2,"ssf":2,"profile":1,"panther":1,"ncbifam":1,"sfld":2,"prints":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":3924}}}