{"metadata":{"accession":"A0A8B7RQS4","id":"A0A8B7RQS4_HIPAR","source_organism":{"taxId":"186990","scientificName":"Hipposideros armiger","fullName":"Hipposideros armiger (Great Himalayan leaf-nosed bat)"},"name":"Cell cycle checkpoint protein RAD1","description":["Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase"],"length":280,"sequence":"MPLLNQQIQDENDYSLTASLDNVRNLSTILKAIHFQEHATCFATKNGIKVTVENAKCVQANAFIQAGIFQEFKVQEEPVTFRINLTVLLDCLSIFGSSSMPGTLTALQMCYQGYGYPLMLFLEEGGVVTVCKINTQEPEETLDFDFCSTNVINKIILQSEGLREAFSELDMTSEVLQITMSPDKPYFRLSTFGNAGSSHLDYPKDSDLMESFNCTQNQVNRYKISLLKPSTKALVLSCKVSIRTDNRGFLSLQYMIRNDDGQICFVEYYCCPDEVPEPDS","proteome":"UP000694851","gene":"RAD1","go_terms":[{"identifier":"GO:0000077","name":"DNA damage checkpoint signaling","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005634","name":"nucleus","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"e59869a3a1f0afa6e9d7791e55c69aa30288536e","counters":{"domain_architectures":4038,"entries":10,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"cdd":1,"ssf":1,"panther":1,"pfam":1,"prints":2,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":4038}}}