{"metadata":{"accession":"A0A8B7PZL5","id":"A0A8B7PZL5_HIPAR","source_organism":{"taxId":"186990","scientificName":"Hipposideros armiger","fullName":"Hipposideros armiger (Great Himalayan leaf-nosed bat)"},"name":"Serine protease HTRA3","description":["Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans. May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization"],"length":496,"sequence":"MWPRARPRPLRRRPAPGPSAASVSPPASGRSSALPPAPGPSAMQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGRPLDSPCGESLECTRGVCRCRWAHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPSGLHQLTSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIVTNAHVVSSTKALSGRQQLKVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLPALLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGKELGLRDSDMDYIQTDAIINVSALSPAPGPHPDGEVIGINTLKVAAGISFAIPSDRIVRFLTEFQDKHVKDWKKRFIGIRMRTITPSLVEELKASNPDFPEVGSGIYVQEVVPNSPSQRGGIQDGDIIVKVNGRPLADSSELQEAVLTESPLLLEVRRGNDDLLFNIAPEVVL","proteome":"UP000694851","gene":"HTRA3","go_terms":[{"identifier":"GO:0005576","name":"extracellular region","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004252","name":"serine-type endopeptidase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006508","name":"proteolysis","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"7b375b02671c9e36f05a591177bc204239049686","counters":{"domain_architectures":611,"entries":30,"isoforms":0,"proteomes":1,"sets":5,"structures":0,"taxa":1,"dbEntries":{"profile":3,"smart":3,"ssf":4,"pfam":4,"cathgene3d":4,"cdd":2,"panther":1,"prints":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":611}}}