{"metadata":{"accession":"A0A7M7JR73","id":"A0A7M7JR73_VARDE","source_organism":{"taxId":"109461","scientificName":"Varroa destructor","fullName":"Varroa destructor (Honeybee mite)"},"name":"E3 ubiquitin-protein ligase CBL","description":["E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome"],"length":590,"sequence":"MTCNPLSVAYNLKHPFCLFGATLRLQQTFVCLHPSNTICCFDPGRTGLHRLSMLETCHTVSRRYFCSRGRIVEMATAAPPGQLNISALFSKLLSTNPPRFVIERKTIEKTWKLMDKVVKLCQQPRVNLKNSPPFILDLLPDTYQHLRLVYARYELEMHVLNENEFFREFLANLARKCKQANKLFKEGKERMFDETSPQRRNLTKLSLVFSHMLAELKALFPDGSFAGDSFRITKADAETFWRSNFGNKTIVRWSEFRRVLHSVHPISSVLESMALKATIDLTCNDFISCFEFDVFTRLFQPWQSLLRNWQILAVTHPGYVAFLTYDEVKARLSAYLDKPGAYVFRLSCTRLGQWAIGYVTADGRIFQTIPQNKSLCQALLDGNKDGSYLYPDGRAVNPDLSFAVREEPEDHIQVSQEQYELYCEMGSTFQLCKICAENDKDIRLEPCGHLLCTPCLSAWQESDGSGCPFCRQDIRGTEQIIVDPFNQQNNNDDLPLLHNPQQQPLLQQQRSPCQLQPQLQLHQLQQLQQQGTQQSQQQQQLQESQPLQYQTQNQDRSTTTVSSSILTDTTSAVFAQASSSTQQSHQQKGS","proteome":"UP000594260","gene":null,"go_terms":[{"identifier":"GO:0007166","name":"cell surface receptor signaling pathway","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0001784","name":"phosphotyrosine residue binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005509","name":"calcium ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004842","name":"ubiquitin-protein transferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0023051","name":"regulation of signaling","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"5755de97b2c67c9577866bcc8fa78e19f9d4d950","counters":{"domain_architectures":1157,"entries":31,"isoforms":0,"proteomes":1,"sets":5,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":4,"profile":2,"ssf":4,"pfam":4,"cdd":2,"smart":1,"panther":1,"prosite":1,"interpro":12},"proteome":1,"taxonomy":1,"similar_proteins":1157}}}