{"metadata":{"accession":"A0A7L0BH32","id":"A0A7L0BH32_9AVES","source_organism":{"taxId":"252798","scientificName":"Spizaetus tyrannus","fullName":"Spizaetus tyrannus (black hawk-eagle)"},"name":"Sterol carrier protein 2","description":["Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol. Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs","Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs"],"length":521,"sequence":"QFTKPDEKSVDYPDMAKEAGQKALADAGILYSEVEQACVGYVYGDSTSGQRAIYHGLGLTGIPITNVNNNCATGSTALFMARQLVEGGLANCVLALGFERMAKGSLASGFSDRTNPIDKHLEIMINKYGLASAPVAPQMFANAGKEHMEKYGTNPEYFAKIAWKNHSHSTNNPYSQFQKEYTLDEVLHSRKIFDFLTVLQCCPTSNGAAAAVLASEEFVKKRKLQPKAVEILAQVMVTDYPSTFEENSCMKLVGYDMTKKAAEKCFEKAGLKPTDVDVIELHDCFSVNELITYEALGLCPEGRACDLIDRGDNTYGGKWVINPSGGLISKGHPLGATGLAQCAELCWQLRGLAGRRQVPGAKVALQHNLGVGGAVVVTLYGMGFPGAASTGRIAAVPLSAAVEGFKSHLVFKEIEKKLQEEGEQYVKKIGGVFAFKIKGGPGGKEATWIVDVKNGKGSVAVNSDKKADCTITMADTDLLALMTGKMNPQTAFFQGKLKVSGNMGMAMKLQNLQLQPGKAKL","proteome":"UP000519115","gene":"Scp2","go_terms":[{"identifier":"GO:0016746","name":"acyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016747","name":"acyltransferase activity, transferring groups other than amino-acyl groups","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":true,"in_alphafold":true,"in_bfvd":false,"ida_accession":"2439a6bccc43aa4dc3392b487f93078cdae62632","counters":{"domain_architectures":1551,"entries":19,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cdd":1,"cathgene3d":2,"pfam":3,"ssf":2,"ncbifam":1,"panther":1,"prosite":2,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":1551}}}