{"metadata":{"accession":"A0A7J8HTW5","id":"A0A7J8HTW5_ROUAE","source_organism":{"taxId":"9407","scientificName":"Rousettus aegyptiacus","fullName":"Rousettus aegyptiacus (Egyptian fruit bat)"},"name":"Parathyroid hormone/parathyroid hormone-related peptide receptor","description":["G-protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. PTHLH dissociates from PTH1R more rapidly than PTH; as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH"],"length":590,"sequence":"MGAARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPADIMESDKVWASASTSGKPRKEKASGKLFPDSEEDKELPTGSRRRGRPCLPEWDHILCWPPGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGATLDEAERLTEEELRAIAQAPPPPAAAAAGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAIFVAVWVSVRATLANTGCWDLSSGNKKWIIQVPILASIVLNFVLFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEVKKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRAGLGLPLSPRLLPAATTNGHAQLPGLTKPGAPALQATPPAVATPKDDGFLNGSCSGLDEEASAPERPPALLQEEWETVM","proteome":"UP000593571","gene":"HJG63_016125","go_terms":[{"identifier":"GO:0004930","name":"G protein-coupled receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0007186","name":"G protein-coupled receptor signaling pathway","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004888","name":"transmembrane signaling receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007166","name":"cell surface receptor signaling pathway","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004991","name":"parathyroid hormone receptor activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"698a44734e6852726f7714e7370e1a4e9c280ea3","counters":{"domain_architectures":20578,"entries":22,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"profile":2,"smart":1,"ssf":2,"cdd":1,"pfam":2,"panther":1,"prosite":2,"prints":2,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":20578}}}