{"metadata":{"accession":"A0A7J8FGW4","id":"A0A7J8FGW4_ROUAE","source_organism":{"taxId":"9407","scientificName":"Rousettus aegyptiacus","fullName":"Rousettus aegyptiacus (Egyptian fruit bat)"},"name":"Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1","description":["Rate-limiting enzyme of the hexosamine biosynthetic pathway (HBP) that catalyzes the formation of glucosamine-6-phosphate from fructose-6-phosphate and glutamine, thereby controlling the flux of glucose into this pathway. Inhibited by UDP-N-acetylglucosamine (UDP-GlcNAc) through a feedback loop. Fine-tunes the metabolic fluctuations of UDP-GlcNAc and its impacts on hyaluronan synthesis during tissue remodeling. Via control of the HPB, regulates the availability of precursors for N- and O-linked protein glycosylation and modulates peripheral clock oscillation"],"length":681,"sequence":"MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGVDGGNDKDWEANACKIQLIKKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPSPVNSHPQRSDKNNEFIVIHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNRESQDISFTTLVERVIQQLEGAFALVFKSVHFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTGKDKKGSCNLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVAAVVDGRLSIHRIKRTAGDHPGRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLMGLRYCKERGALTVGITNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEILLGLKRLPDLIKEVLSMDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELKHGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE","proteome":"UP000593571","gene":"HJG63_005567","go_terms":[{"identifier":"GO:0097367","name":"carbohydrate derivative binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:1901135","name":"carbohydrate derivative metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004360","name":"L-glutamine:D-fructose-6-phosphate transaminase (isomerizing) activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:1901137","name":"carbohydrate derivative biosynthetic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"4939bf430566eb36e0203585ecbd9dd7ebb6a661","counters":{"domain_architectures":21075,"entries":22,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cdd":3,"profile":2,"ssf":2,"cathgene3d":2,"pfam":2,"panther":1,"ncbifam":2,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":21075}}}