{"metadata":{"accession":"A0A6P8VT41","id":"A0A6P8VT41_GYMAC","source_organism":{"taxId":"8218","scientificName":"Gymnodraco acuticeps","fullName":"Gymnodraco acuticeps (Antarctic dragonfish)"},"name":"Rho-related GTP-binding protein RhoG","description":["Plays a role in immunological synaptic F-actin density and architecture organization. Regulates actin reorganization in lymphocytes, possibly through the modulation of Rac1 activity. Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. Binds phospholipids in an activation-dependent manner; thereby acting as an anchor for other proteins to the plasma membrane (PM). Plays a role in exocytosis of cytotoxic granules (CG) by lymphocytes/Component of the exocytosis machinery in natural killer (NK) and CD8+ T cells. Promotes the docking of cytotoxic granules (CG) to the plasma membrane through the interaction with UNC13D. Involved in the cytotoxic activity of lymphocytes/primary CD8+ T cells"],"length":191,"sequence":"MQTIKCVVVGDGAVGKTCLLISYTTNAFPEEYIPTVFDNYSAQMSVDGRTVSLNLWDTAGQEEYDRLRTLSYPQTNVFIICFSIGSPSSHANVRHKWHPEVSHHCPNVPIMLVGTKRDLRGDAETVKKLKEQGLAPTTQQQGNALAKQIGAVKYMECSALLQDGVREVFAEAVRAVLYPVTKKNPKKCVLL","proteome":"UP000515161","gene":"LOC117556949","go_terms":[{"identifier":"GO:0005525","name":"GTP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003924","name":"GTPase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007264","name":"small GTPase-mediated signal transduction","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"31aa1b32c82271990f81b4779ae58d1cb9b14b00","counters":{"domain_architectures":273930,"entries":17,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"ncbifam":1,"profile":3,"smart":4,"cathgene3d":1,"ssf":1,"pfam":1,"panther":1,"prints":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":273930}}}