{"metadata":{"accession":"A0A6P8RIK8","id":"A0A6P8RIK8_GEOSA","source_organism":{"taxId":"260995","scientificName":"Geotrypetes seraphini","fullName":"Geotrypetes seraphini (Gaboon caecilian)"},"name":"Fucosyltransferase","description":["Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins. Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins. Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis. In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE"],"length":341,"sequence":"MAKRRRTPRRRCRRRLLAAALTCTALAVYAACGHELARLLRPPPAQTVTVLLWGETFGERPRPGDCKLLFDISDCNVTTDRGRLGQAQAVLFHHHDLGGALPAERPAGQRWVWMNFESPSNTAGLRELGGVFNWTMSYRVGSDIFLPYGYLYARRKEAAAARLPRKSKLLAWVISNWGEEQERVQYYRRLARHVRVDVYGRAGLRLPGDSVLRAVSRYKFYLAFENSQHPDYITEKLWRNAFGASAVPVVLGPSRANYELFVPGDSFIHVDDFSSPRKLAGYLKLLDRNPPLYRRYFAWRKRYQVHVASFWSEHFCTVCQAVRVAGDQLKTVHDLAGWFES","proteome":"UP000515159","gene":"FUT4","go_terms":[{"identifier":"GO:0008417","name":"fucosyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0009101","name":"glycoprotein biosynthetic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"7949b5825a229418c69f4bf07e7a1deea5b39a63","counters":{"domain_architectures":11385,"entries":9,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"pfam":2,"cathgene3d":1,"panther":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":11385}}}