{"metadata":{"accession":"A0A6P6CVK7","id":"A0A6P6CVK7_PTEVA","source_organism":{"taxId":"132908","scientificName":"Pteropus vampyrus","fullName":"Pteropus vampyrus (Large flying fox)"},"name":"FERM domain-containing protein 8","description":["Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface. Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6"],"length":465,"sequence":"MDGTESSAGQPGPSERSHRSSVSSMGARAADVLVYLADDSVVPLAVENLPSFSAHELHRAIREVLQLPDIALDAFALWLVSPLLEVQLKPKHQPYKLGRQWPELLLRFTDAPDDDVATDEPSLQFRRNVFFPKRRELQIRDEEVLRLLYEEAKGNVLAARYPCDVEDCEALGALVCRVQLGPYRPGQPTACTLREKLGSFLPAHLCKRGHGLFAALRGRGTKAGTGEQGLLDAYRKVKEVVGSDSECEAPLGTHYHAYLLKCHELPFYGSAFFHGEVDKPAQGFLPRGGRKPVTVAISLEGVHVMDSREKHVLLGLRFQELSWDHTSPEEEESVLWLEFDGNNEGTPVNKLLKIYSKQAELMSSLIEYCIELNQAMEPAAPAESASGSPSIPSSPPPPTQRPQLRRQGSVVCSRIQHLSTIDYVEEGEQIKRVKPKRTTSFFSRQLSMGQGSYTVVQPAESPEQS","proteome":"UP000515202","gene":"FRMD8","go_terms":null,"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"fcf976a4894c185bae91011ff3d1573bba7dd818","counters":{"domain_architectures":1187,"entries":18,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"smart":1,"profile":1,"ssf":1,"pfam":2,"cdd":1,"panther":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":1187}}}