{"metadata":{"accession":"A0A6P6BYH0","id":"A0A6P6BYH0_PTEVA","source_organism":{"taxId":"132908","scientificName":"Pteropus vampyrus","fullName":"Pteropus vampyrus (Large flying fox)"},"name":"Endonuclease 8-like 1","description":["Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC"],"length":389,"sequence":"MPEGPELHLASHFVNEACRDLVFSGCVEKSPISRNPEVPFESSAYHISALARGKELRLTLSPLPGAQPLREPLALVFRFGMSGSFQLAPSDALPPHAHLRFYTAPPSPGLALCFVDIRRFGHWELGGKWQPGRGPCVLLEYEQFRENVLRNLVDKAFDRPICEALLDQRFFNGIGNYLRAEILYRLKIPPFEKARTVLEALQQRRPSPELTLSQKIRAKLQNPDLLELCHSVPKEVVQLGGKGYGQESGEDDYAAFRAWLQCYGMAGMSSLRDRHGRTIWFQGDPGPLAPKGGRPHKKKSKGAQQSPEDKMENPPPPSKAPSKTRRARRGLPEQTTAQQPKRTSLQQDPGVSPVTEKGKRRGRQASGFCRPQRIKADTSSLETEGTSAS","proteome":"UP000515202","gene":"NEIL1","go_terms":[{"identifier":"GO:0003906","name":"DNA-(apurinic or apyrimidinic site) endonuclease activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008270","name":"zinc ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0019104","name":"DNA N-glycosylase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006284","name":"base-excision repair","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003676","name":"nucleic acid binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003684","name":"damaged DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016799","name":"hydrolase activity, hydrolyzing N-glycosyl compounds","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"a3c48f027a33489e7a21b1cb4e22b7d0c8aee9f7","counters":{"domain_architectures":875,"entries":16,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"pfam":2,"cathgene3d":2,"profile":1,"smart":2,"ssf":3,"panther":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":875}}}