{"metadata":{"accession":"A0A6P5QIC0","id":"A0A6P5QIC0_MUSCR","source_organism":{"taxId":"10089","scientificName":"Mus caroli","fullName":"Mus caroli (Ryukyu mouse)"},"name":"Checkpoint protein","description":["Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase"],"length":300,"sequence":"MKFRAKIVDLACLNHFTRVSNMIAKLAKTCTLRISPEKLNFILCDKLASGGVSMWCELEQENFFSEFQMEGVSEENNEIYLELTSENLSRALKTAQNSRALKIKLTNKHFPCLTVSVELQVSSSSSSRIVVHDIPIKVLPRRLWKDLQEPSIPDCDVSICLPALKMMKSVVEKMRNISNQLVIEANLKGELNLKIETELVCVTTHFKDLENPLLPSDSVSQNRHPEDMAKVHIDIKKLLQFLVGQQVTPTKAVCSEFASPLLTSCVLHMQVCPVLGIELAETVSLESSLEPEVSRDAEEE","proteome":"UP000515126","gene":"Hus1","go_terms":[{"identifier":"GO:0000077","name":"DNA damage checkpoint signaling","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005730","name":"nucleolus","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0030896","name":"checkpoint clamp complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"e13f25288c22582ba571297bd69358800cef8732","counters":{"domain_architectures":4393,"entries":8,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pirsf":1,"pfam":1,"panther":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":4393}}}