{"metadata":{"accession":"A0A6P5IM60","id":"A0A6P5IM60_PHACI","source_organism":{"taxId":"38626","scientificName":"Phascolarctos cinereus","fullName":"Phascolarctos cinereus (Koala)"},"name":"Tubulin polyglutamylase TTLL11","description":["Polyglutamylase which modifies tubulin, generating polyglutamate side chains of variable lengths on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Preferentially mediates ATP-dependent polyglutamate long side-chain elongation over the initiation step of the polyglutamylation reaction. Preferentially modifies the alpha-tubulin tail over a beta-tail. Required for CCSAP localization to both spindle and cilia microtubules. Promotes tubulin polyglutamylation which stimulates spastin/SPAST-mediated microtubule severing, thereby regulating microtubule functions"],"length":726,"sequence":"MQRACGDGPAELPALEDPGAEGEPDPKAKQNEQRPEPKPDTEPEPELDTKLEPDADPAPDPEPAPAPEPEPERPAEAELQTRVPSSAPLTVQNPAEQGDVSLQERRPRPVARIRTKTKGKKAAGVRVPDESRGRRPLTVTVDSSKARTSLEALKISLRQLKWREFPFGRRLPCDIYWHGVSFHDSDILSGQVNKFPGMTEMVRKITLSRAVRIMQDLFPEEYNFYPRSWILPDEFQLFVAQVRMVKDGDPSWKPTFIVKPDGGCQGDGIYLIKDPSDIRMAGNLQSRPAVVQEYICKPLLIDKLKFDIRLYVLLKSLEPLEIYIAKDGLSRFCTEPYQEPNFGNLHHVFMHLTNYSLNIHSGNFIHSDNANTGSKRTFSSILCRLSSKGVDIKKIWSDIISLVIKTVIALTPELKVFYQSDIPAGRPGPTCFQILGFDILLMKNLKPMLLEVNANPSMRIEHEQELSPGVFENVPSLVDEEVKVAVIRDTLRLIDPLKNKKKENRSEQCNKISGMREESREGTDEPQPEDIFDAEAYMNNEASLPSICLKQVFPKYAKQFNYLRLVDRMANLFIRFLGIKGTTRLGPTGFRTFIRNCKLSSSTFSMASVDILYIDITRRWNSMGLEQKESGMCLQAFVEAFFFLAQRRFKHSSLQEQVASLVDLCEYHLTLLDEKRLLCSKGTSSGRPPNSSSSQERLPLTQPPNGSFLPRNNTANKFAHYRHPQS","proteome":"UP000515140","gene":"TTLL11","go_terms":[{"identifier":"GO:0036211","name":"protein modification process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"14078f108af716932125402dd78ea3e32dec3688","counters":{"domain_architectures":1098,"entries":8,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"profile":1,"ssf":1,"cathgene3d":1,"pfam":2,"panther":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":1098}}}