{"metadata":{"accession":"A0A6P4EN26","id":"A0A6P4EN26_DRORH","source_organism":{"taxId":"1041015","scientificName":"Drosophila rhopaloa","fullName":"Drosophila rhopaloa (Fruit fly)"},"name":"UPAR/Ly6 domain-containing protein qvr","description":["Bifunctional regulator of neuronal activity in the mushroom body, and possibly other regions of the brain, that acts as a signaling molecule required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Reduces neuronal excitability by enhancing Sh/shaker K(+) channel activity; possibly by stabilizing Sh/shaker to increase protein levels, accelerating its activation kinetics, slowing C-type inactivation and enhancing recovery from inactivation. Specifically affects the A-type K(+) current. Antagonizes nicotinic acetylcholine receptors (nAChRs) to reduce synaptic transmission, possibly by preventing their localization to the cell surface. Required for regulation of neuromuscular excitability and plasticity at neuromuscular junctions"],"length":155,"sequence":"MWTQRNAVGNWLLVLTVFLALAKFATTDNCFPTRSIYCYECDSWTDARCKDPFNYTALPRDQPPLMTCNGCCVKMVRHQRSPYEVVRRMCTSQLQINLFMVDHVCMMESSGNGHMCFCEEDMCNSSKDLLTNGCQLHLIPIAVAVSWLMGQLLSR","proteome":"UP001652680","gene":"LOC108044843","go_terms":[{"identifier":"GO:0030431","name":"sleep","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0032222","name":"regulation of synaptic transmission, cholinergic","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:1903818","name":"positive regulation of voltage-gated potassium channel activity","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"0fc4b25e7d1b431d99e58c4f149d83ffaa95601d","counters":{"domain_architectures":6763,"entries":5,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cdd":1,"pfam":1,"panther":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":6763}}}