{"metadata":{"accession":"A0A6P3VLX0","id":"A0A6P3VLX0_CLUHA","source_organism":{"taxId":"7950","scientificName":"Clupea harengus","fullName":"Clupea harengus (Atlantic herring)"},"name":"TGF-beta-activated kinase 1 and MAP3K7-binding protein 1","description":["Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines. Mechanistically, associates with the catalytic domain of MAP3K7/TAK1 to trigger MAP3K7/TAK1 autophosphorylation leading to its full activation. Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation. In turn, MAPK14 phosphorylates TAB1 and inhibits MAP3K7/TAK1 activation in a feedback control mechanism. Also plays a role in recruiting MAPK14 to the TAK1 complex for the phosphorylation of the TAB2 and TAB3 regulatory subunits"],"length":502,"sequence":"MAAQRRNLMQSHQSWTDDLPLCQLCGVGNSPNCVYGQDGKGAQSHPYEDGHFRFRGEDCSLYGVFNGYDGSRVANFMSQCLTAELLLGQLNTTHSDADVRRILSQAFDAVEKSYFETIGDALAEKANLQSQLPEGAIFHQLSPQSQKLADRLAALEQEVNGGATAVVALILNNKLYIANVGTNRALLCKSTSDGQNQVIQIGRAHTTDNDDELTRLVQLGLDANRLRQTSLIAGQSSTRRIGDYKVKFNYTDIDVLSAAKNKPIIAEAEIHGGQSLEGVTGFLLLMSEGLIKALESAHGPEQANQEMVAMVAAELAQQSTLEAAAQSVVERVKRLHHDAFVSGRQRASHCSRHEDMTLLVRLINYPLPDGTLTPTQGGRIYPVSVPYSSSQNTSKTSVTLSLVMPSQGGTLTNGTNTASTLDGGTPTPGQSPTATLQSTNTQTQSSSSSSGDGSLFRQRGSQAAQPDETGRVPPYVDFTEFYQLWGSDHNDGQSTQGGLGPQ","proteome":"UP000515152","gene":"tab1","go_terms":[{"identifier":"GO:0004722","name":"protein serine/threonine phosphatase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006470","name":"protein dephosphorylation","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"9761dfa8fcbc09f23441e5fd2f8dffed523952dd","counters":{"domain_architectures":75992,"entries":10,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"smart":1,"cdd":1,"profile":1,"ssf":1,"panther":1,"pfam":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":75992}}}