{"metadata":{"accession":"A0A6P3ISA9","id":"A0A6P3ISA9_BISBB","source_organism":{"taxId":"43346","scientificName":"Bison bison bison","fullName":"Bison bison bison (North American plains bison)"},"name":"Caspase recruitment domain-containing protein 14","description":["Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases. May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis"],"length":1002,"sequence":"MAELCRTDSSLTSLDEEVLWEMMEDHRCRIVRSIFPSRLTPYLRQAKVLDQLDEEEVLHSPRFNNTAMRVGYLLDLLKTRGKNGAIAFLESLKFHNPDVYTLVTGLQPSVDFTNFSGLMETSKLTECLAGAIGSLQEELSQEKGQKEALLRQCQQLQERLDQAEARAEGLRQLEADHSRMKREVSAHFHEVLKLKDEMLSLSLHYSNALQEKELATTRCRSLQEELYLMKQELQREKMSSSCEREFRERSLKMASDLEPGDEELSRLKEENERLRSLTFSLVEKDILEQNLDEALESRQELVDRIHSLRERAVAAERQRKQYWEEKEQTLLQFQKTKVDCEIYKEKMNALQSQVVELQKERDQAYSARDGAQMEISQNLTEKDALRRKVFELMDQVCELRQQVQRLRVQADSSPGVSAQEVGAREPCPKGKQRLVRMFALCPRDDSNGSSSESQLWSDLSATSSRELVDSFRSSSPAPPSQQSLCKRATEDFWEDPCSSSGCPEILEVDQGGSLVAKKSNADLDFEIVDRADLPESENSLQPSSGDLYLSASCFPVRRRPARKILSQVTVLAFQGDALLEQISVIGGNLTGIFIHRVTLGSAADEMALRSGTQIVMVDYEATEPSSKAVLEGMTLERAVGLLQRVNGFCCLSVKVNMEGYKKLVQDLEAKVATSGDSFYIRVNLALEGRAEGELQVRCNDILHVTDTLFQGSSCWHAHRVGPYSTKGTKHGTIPNYTRAQQLLIALLQDMAHQSTVTRKQSSGGAQKLVRIVSMDRTKASPLWSSFEGSQSDPSRVEGEVDPSTVCFWTESCFTLVPYTLVHPHRPSRPRPVLFVPRVVGKILIEKLCLFQGFKKCPAEYLSQEEYDTSSQRGDIIQEREASGGLYCVTRRAVESLMGKNTHALLDIQLDSVCVLHRMEIFPIIIHVSINEKVAKKFKKALQRLGTTEDQLLEAARQEEAELDKVPCLYSSLAPESWSDLDALLGCVRLAITDEQRKVVWTE","proteome":"UP000515208","gene":"CARD14","go_terms":[{"identifier":"GO:0042981","name":"regulation of apoptotic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"eede5dad5920dee99d1cbc6b0c16446cf5c706e9","counters":{"domain_architectures":8648,"entries":19,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"profile":3,"cathgene3d":4,"ssf":3,"pfam":1,"cdd":1,"panther":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":8648}}}