{"metadata":{"accession":"A0A6J3INL9","id":"A0A6J3INL9_SAPAP","source_organism":{"taxId":"9515","scientificName":"Sapajus apella","fullName":"Sapajus apella (Brown-capped capuchin)"},"name":"Beta-3 adrenergic receptor","description":["G protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, leading to either activation or inhibition of adenylate cyclase and cAMP-dependent pathway, respectively. The rank order of potency for physiological agonists is norepinephrine > epinephrine. Involved in the regulation of thermogenesis and lipolysis in brown and white adipose tissue, after coupling to G(s) proteins and stimulation of the cAMP-PKA axis. Also activates lipolytic process by coupling to G(i) proteins and consequent initiation of the ERK1/2 MAP kinase cascade. Participates in relaxation of the blood vessels and the urinary bladder. Also mediates negative inotropic effects in cardiomyocytes through activation of an NO synthase pathway and subsequent increase in cGMP levels, possibly involving G(i/o) protein-mediated coupling"],"length":410,"sequence":"MTPWPHGNSTLAPWPDVPNTANTSGLPGVPWAAALAGALLALAVLATVGGNLLVIVAIARTPRLQTMTNVFVTSLATADLVVGLLVVPPGATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYSALVTKRRARAAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNLPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELRRFPPEESPPAPSRTLAPARAGTCALAEAVPACGRRPERLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRGGACLPLEPRAAASPALVPPGASAARTSPAQPRLCRQLDGFDGRGGENPLPV","proteome":"UP000504640","gene":"ADRB3","go_terms":[{"identifier":"GO:0004930","name":"G protein-coupled receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007186","name":"G protein-coupled receptor signaling pathway","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0004939","name":"beta-adrenergic receptor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007189","name":"adenylate cyclase-activating G protein-coupled receptor signaling pathway","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004935","name":"adrenergic receptor activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"587fa3dbe4504dc051049f3cca904dd9ab631b87","counters":{"domain_architectures":340616,"entries":14,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"smart":1,"pfam":1,"profile":1,"panther":1,"prosite":1,"prints":3,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":340616}}}