{"metadata":{"accession":"A0A6J3DSX6","id":"A0A6J3DSX6_AYTFU","source_organism":{"taxId":"219594","scientificName":"Aythya fuligula","fullName":"Aythya fuligula (Tufted duck)"},"name":"E3 ubiquitin-protein ligase XIAP","description":["Multi-functional protein which regulates not only caspases and apoptosis, but also acts as an E3 ubiquitin-protein ligase mediating ubiquitination and subsequent proteasomal degradation of its target proteins. Acts as a direct caspase inhibitor. E3 ubiquitin-protein ligase that acts as an important regulator of innate immunity by mediating 'Lys-63'-linked polyubiquitination of ripk2 downstream of NOD1 and NOD2, thereby transforming ripk2 into a scaffolding protein for downstream effectors, ultimately leading to activation of the NF-kappa-B and MAP kinases signaling. A key apoptotic suppressor in eggs. Acts as a positive regulator of Wnt signaling"],"length":493,"sequence":"MTCNGPGNSEPHATPGTDYDQDWAQEHHRLGSFAEFPLDCLVSASALAQAGFVYTGEGCKVKCFSCHVTIEGWQPGDSAVERHKNLSPNCKFITESTFLENDLRPLAQNYQHRAENGSSNSVLLPALDDSPELEADYLLRTRQVVDMSDILYPKNPAMCSEEARLKSFHNWPSYGLLAPKELASAGLYYTGVGDQVACFCCGGKLKNWEPSDRAWSEHKRHYPRCYFVLGRDVGNVPSESIPAELGRNGLNDEQHPRNPSMAEYERRIQTFLNWIYPVNKEQLAEAGFYSIGNGDHVVCFHCGGGLQEWKENEDPWDQHAKWFPGCRFVREEKGLEFINNVHLGGGCRDSTIEAAEVTVLPKDDHLQNHLVQNAIHMGFSLSEIKSIMQKKLQMSGASYTSVEDLVADLISAQKENLKEEIPNENPLDQDLSMEEKLRRLQEEKLCKICMAKDISVVLIPCGHLVACKECAEAVNVCPLCCTNILKRQKIFMY","proteome":"UP000504639","gene":"XIAP","go_terms":null,"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"24cd8ffd9fbb9912c7fdde133e9845921a373549","counters":{"domain_architectures":556,"entries":20,"isoforms":0,"proteomes":1,"sets":5,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"ssf":1,"smart":2,"cdd":2,"pfam":3,"profile":2,"panther":1,"prosite":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":556}}}