{"metadata":{"accession":"A0A6J3CP50","id":"A0A6J3CP50_AYTFU","source_organism":{"taxId":"219594","scientificName":"Aythya fuligula","fullName":"Aythya fuligula (Tufted duck)"},"name":"Desmoplakin","description":["Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance"],"length":2263,"sequence":"MSMNGGSHPRLNTLGRMARADSGTDLRYEMSSHVVSGGGGGTHTHKTYYYQKTYGGDYASDGYGQNGTCTVSRRQNTIQELLQNCSDCLMRAELIVQPELKYGDGVQIRGNRDLEECFAQANDQMDILDGLIRELRQMNQPCEMYQKRLLQLQEQMRALYKAISVPRARRASSKGGGCYSSQSGSGWDEYTKRVTSECLNWMRQQKSEMELVKWGFDAASIEQQISDHRRTHNAIGDYRWHLDKVKTDLREKAAVHQLEEEYEGLLKYSFERMDQLRQFQNLIQATSREIMWINDCEEEELLYDWSDRNTDIARKQEAFSKRMSELELKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQATECYLKNLQDSIRKKFMCDKSMSLQCLLEQIKELENERERILEYKRQVQSLVNKSKKIVQLKPRNPDYRSNKPIILKALCDYKQDLKTVRKGDECILKDNNERSKWLVTGPGGVDMLVPSVSLIIPPPNPLAVDLATKIEQYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRKEDYQKIITDLEIHYQEFLRNSQGSEMFGDEDKRKMQTQFTDAQKHYQTLIIQLPNQPRQPQPVIPTETCPVGSSNTIIVNERNREHDKQEAWLLMELQKLRRQIESSEIRMVQRAPLGVDQGALHDFSVRIQELEGVQNDSQIMAETLNKHKDLLPNFRGCEKYVYLQSEINALFQKLENINGVSAGYLDSLNVLRCLLQLILQTEDVIRVFEVRLSEEETVPLDLDKVEAYRACLKKMKADLNMKKSLLNALENELQKMLQIHSQSCQSYTLYDMDIGKFSDKVTQLIDRWQRAEKQIDNRSWDLERQIKQLKTYRDLYQALCKWICDAKRRQDSIESMKLCDSNTIMRYLHDQKNLHSEICGKRDKVEELLKHADQCSAAIKDYELQVASYSSGLETLLNIPIKKCVVQSPAVLILQEASEAQARYIELLTRSGDYYKFLSEMLKSMEDLKMKATKIELLEEELRLARDSNSETNNKHKFLEQNLQKYQMDISQLKAKLMSLEEMKRQAEMDGNSAKQNLDKCYAQIKDLNDRITRLTYETEDEKRKRKLLEDRYEQQKNDYDQLQKTRQNEKDSLGWQKLESEKVIKEKEYEIERLRVLLQDEGTRKREYENELAKASNRIQESKNQYSHIMQERETLLIKMSALEQDKARLQRLEEELNRLKVSLESESRLKQRLESEKQQILNDLNQWKSQHSRTEESIRKIQCEREKSEREKNTLRTEIERLQMEIKRIEERYRCRLEETAVKNQSELESERLRLQREIEKLKQRPYGSHRSTQTEEDFCIDASKLLFSGLRKKITAMQLYECQIIDKVTLDKLLKGQRSVEEVAADIEPYLKGAGAIAGVSVLPRQKYSFVEAKRNQLLTAENAVLLLEAQAATGGVIDPHRNEVLTVDSAIARDLIDFDDREQIYTAEKAITGFKDPFSGKTVPLSEAIKKNLVDRETGIRLLEAQLAVGGIVDPVNSVFLPKDIALSRGLIDKDLYRILNNCQSATKNFIDPTTKKAVTYMQLKEKCRIEPHTGLLLLPVQKRSMSFQGIRQPVSADALLEAGIIKESTRNDLERGAITVEEVSERIIDFLQGSSCIAGIYNEATKEKLGIYQAMKIGLVRPGTALELLEAQAATGFIVDPVSNVRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYKDPETGNIISLFQAMNKELIERGHGIRLLEAQIATGGIIDPKESYRLPVETAYKRGYFNEELNQILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEATGLCLLPLREKKKVVHTSQKNTLRKRRVVIVDPETNREMSVQEAYSKGLIDYDTYTELAEQECEWEEITITGSDGSSRVVLVDRKTGSQYDIQDAIDKGLVERKFFDQYRSGSLSLTQFADMISCRNGTDEVFRHESVTRSPTVLSVRSSSSMIRSGSFSETTEECSPIAAIFDTENLEKISISEAIQRGIVDSITGQRLLEAQACTGGIICPTTGQRLSLQEATSQGIVDQDMATRLKPAQKAFLGFEGIKGGRKRMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVRGRISTEEAIRNGLIDGRAAQKLQDTNSYPKILTCPKTKLKISYKDAMNRSMVEDITGLKLLEAASVSSKGISSPYNVSSAPGSRSGSRSGSRSGSRSGSRRGSFDASATSSYSYSYSTFSSGSIGR","proteome":"UP000504639","gene":"DSP","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005856","name":"cytoskeleton","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0045104","name":"intermediate filament cytoskeleton organization","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"357cdbaead1c2edeeb3dccdb6fecfb8a8b48eea2","counters":{"domain_architectures":506,"entries":24,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":5,"cdd":1,"ssf":2,"pfam":6,"profile":1,"smart":1,"panther":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":506}}}