{"metadata":{"accession":"A0A6J2MDC7","id":"A0A6J2MDC7_9CHIR","source_organism":{"taxId":"89673","scientificName":"Phyllostomus discolor","fullName":"Phyllostomus discolor (pale spear-nosed bat)"},"name":"Muellerian-inhibiting factor","description":["Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation and plays a role in Leydig cell differentiation and function. In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression"],"length":600,"sequence":"MSWEMIGAVFQHKHPGPAHISRVAQPFTIPRMWAAPLSRLVLLLWGTLLRAGTPREEALPGESPAGTRGLIFNQDWDWPAPLVWPPSSQQDSLCLVTLGGSGNGSSASLRVVGALRGYEQAFLEALHQAHWGPRDLATFGVCTPSHEHTALTPLQSLQAWLGEPHGQQLVVLHLEEVTWEPTPSLRFQEPPPGESPPELALLVLYPGPGPEVTVTGAGLLGTQSLCLSRDTSYLALAVDHPAGAWQGRGLVLTLQHRGNGTSLSTAQLQLLLFGTDPRCFTRMTPALLLLPRSGRTPMPAQGRQDTVPFPSPSPTLEFKEPQPSADPFLETLTRLVRALRGPPARASLRSLALDPAALVGFPQSLVNLSDPVALERLLDGEEPLLLLSPASATAGDPMSPQGPVSSPWAADLAHRVASELQAAAAELRGLPGLPPAAPPLLARLLELCPGDPGDSGGPGGPLRALLLLKALQGLRTEWRGREWSGPARAQRSAGARAADGACALRELSVDLRAERSVLIPETYQANNCQGSCGWPQSDRNPHYGNHVVLLLKMQARGATLARPPCCVPTAYAGKLLITLSEERISAHHVPNMVATECGCR","proteome":"UP000504628","gene":"AMH","go_terms":[{"identifier":"GO:0008083","name":"growth factor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008406","name":"gonad development","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"22f13bac5db31f04633d2f53e0b703352eccbff6","counters":{"domain_architectures":859,"entries":15,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"profile":1,"cathgene3d":1,"ssf":1,"pfam":2,"smart":1,"cdd":1,"pirsf":1,"panther":1,"prosite":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":859}}}