{"metadata":{"accession":"A0A6J2EEC3","id":"A0A6J2EEC3_ZALCA","source_organism":{"taxId":"9704","scientificName":"Zalophus californianus","fullName":"Zalophus californianus (California sealion)"},"name":"Fructose-bisphosphate aldolase","description":["Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde. Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check"],"length":364,"sequence":"MPYQYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKTDDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKYSHEEIAMATVTALRRTVPPAVTGITFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYVKRALANSLACQGKYTSSGQAGAAASESLFISNHAY","proteome":"UP000515165","gene":"ALDOA","go_terms":[{"identifier":"GO:0004332","name":"fructose-bisphosphate aldolase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006096","name":"glycolytic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"6939a4a3de2ea368cea55eed373bf19a4505ebf3","counters":{"domain_architectures":16537,"entries":10,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"cdd":1,"pfam":1,"panther":1,"ncbifam":1,"prosite":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":16537}}}